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Amyloid-beta neurotoxicity in organotypic culture is attenuated by melatonin: involvement of GSK-3beta, tau and neuroinflammation.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by accumulation of extracellular deposits of amyloid-beta (Abeta) peptide in brain regions that are important for memoryExpand
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Extracellular Nucleotides and Nucleosides Induce Proliferation and Increase Nucleoside Transport in Human Glioma Cell Lines
Extracellular purines (adenosine triphosphate (ATP), adenosine 5′-diphosphate (ADP) and adenosine) and pyrimidines (uridine 5′-triphosphate (UTP) and UDP) are important signaling molecules thatExpand
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Indomethacin-loaded nanocapsules treatment reduces in vivo glioblastoma growth in a rat glioma model.
Multimodal combinations of target agents with radiation and chemotherapy may enhance cancer treatment efficacy; however, despite these treatments, gliomas recur early due to their highlyExpand
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Neuroprotective Effects of Resveratrol Against Aβ Administration in Rats are Improved by Lipid-Core Nanocapsules
Alzheimer’s disease (AD), a neurodegenerative disorder exhibiting a gradual decline in cognitive function, is characterized by the presence of neuritic plaques composed of neurofibrillary tangles andExpand
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Formulation of lipid core nanocapsules
Abstract Polymeric nanoparticle aqueous suspensions have been proposed as drug carriers to improve the efficacy of medicines. Considering those nanocarriers, nanocapsules are vesicular structuresExpand
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The role of ecto-5′-nucleotidase/CD73 in glioma cell line proliferation
Malignant gliomas are the most common and devastating primary tumors in the brain and, despite treatment, patients with these tumors have a poor prognosis. The participation of ecto-5′-NT/CD73 per seExpand
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Characterization of trans-resveratrol-loaded lipid-core nanocapsules and tissue distribution studies in rats.
Several studies have reported that orally ingested trans-resveratrol is extensively metabolized in the enterocyte before it enters the blood and target organs. Additionally, trans-resveratrol isExpand
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Protective effects of indomethacin-loaded nanocapsules against oxygen-glucose deprivation in organotypic hippocampal slice cultures: Involvement of neuroinflammation
Targeted treatment of diseases of the central nervous system remains problematic due to the complex pathogenesis of these disorders and the difficulty in drug delivery. Here we investigate theExpand
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Sustained release from lipid-core nanocapsules by varying the core viscosity and the particle surface area.
Based on the structure of polymeric nanocapsules containing a lipid-dispersed core composed of caprylic/capric trygliceride (CCT) and sorbitan monostearate (SM), we hypothesized that varying the coreExpand
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Resveratrol-loaded lipid-core nanocapsules treatment reduces in vitro and in vivo glioma growth.
The development of novel therapeutic strategies to treat gliomas remains critical as a result of the poor prognoses, inef-. ficient therapies and recurrence associated with these tumors. In thisExpand
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