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Genome evolution across 1,011 Saccharomyces cerevisiae isolates
TLDR
Whole-genome sequencing and phenotyping of 1,011 natural isolates of the yeast Saccharomyces cerevisiae reveal its evolutionary history, including a single out-of-China origin and multiple domestication events, and provides a framework for genotype–phenotype studies in this model organism.
Genomic evidence for the Pleistocene and recent population history of Native Americans
TLDR
The results suggest that there has been gene flow between some Native Americans from both North and South America and groups related to East Asians and Australo-Melanesians, the latter possibly through an East Asian route that might have included ancestors of modern Aleutian Islanders.
A High-Definition View of Functional Genetic Variation from Natural Yeast Genomes
TLDR
It is found that genome content variation, in the form of presence or absence as well as copy number of genetic material, is higher inside S. cerevisiae than within S. paradoxus, despite genetic distances as measured in single-nucleotide polymorphisms being vastly smaller within the former species.
Contrasting evolutionary genome dynamics between domesticated and wild yeasts
TLDR
Long-read sequencing is used to generate end-to-end genome assemblies for 12 strains representing major subpopulations of the partially domesticated yeast Saccharomyces cerevisiae and its wild relative Saccharomers paradoxus to enable precise definition of chromosomal boundaries between cores and subtelomeres and a high-resolution view of evolutionary genome dynamics.
A genomic history of Aboriginal Australia
TLDR
A population expansion in northeast Australia during the Holocene epoch associated with limited gene flow from this region to the rest of Australia, consistent with the spread of the Pama–Nyungan languages is inferred.
Insights into human genetic variation and population history from 929 diverse genomes
TLDR
The authors' study adds data about African, Oceanian, and Amerindian populations and indicates that diversity tends to result from differences at the single-nucleotide level rather than copy number variation.
Establishment of Intestinal Microbiota during Early Life: a Longitudinal, Explorative Study of a Large Cohort of Danish Infants
TLDR
It was found that significant changes in the gut microbiota occurred, particularly from age 9 to 18 months, when cessation of breastfeeding and introduction of a complementary feeding induce replacement of a microbiota characterized by lactobacilli, bifidobacteria, and Enterobacteriaceae with a microbiota dominated by Clostridium spp.
Intake of whole apples or clear apple juice has contrasting effects on plasma lipids in healthy volunteers
TLDR
It is concluded that the fibre component is necessary for the cholesterol-lowering effect of apples in healthy humans and that clear apple juice may not be a suitable surrogate for the whole fruit in nutritional recommendations.
High-Resolution Mapping of Complex Traits with a Four-Parent Advanced Intercross Yeast Population
TLDR
The most parsimonious model for the majority of loci mapped using either approach was the effect of an allele private to one founder, which could validate examples of pleiotropic effects and complex allelic series at a locus.
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