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Genomic Evidence of Rapid and Stable Adaptive Oscillations over Seasonal Time Scales in Drosophila
TLDR
This work hypothesized that environmental fluctuations among seasons in a North American orchard would impose temporally variable selection on Drosophila melanogaster that would drive repeatable adaptive oscillations at balanced polymorphisms, and identified hundreds of polymorphisms whose frequency oscillates among seasons and argued that these loci are subject to strong, temporal variable selection. Expand
Divergence and Functional Degradation of a Sex Chromosome-like Supergene
TLDR
This work uses de novo whole-genome sequencing coupled with population- and phylogenomic data to show that alternate supergene alleles are highly divergent at over 1,000 genes and that these alleles originated prior to the split of Z. albicollis, and provides evidence that the "white" allele may be degrading, similar to neo-Y/W sex chromosomes. Expand
Comparative population genomics of latitudinal variation in Drosophila simulans and Drosophila melanogaster
TLDR
A significant enrichment of shared clinal genes is observed in D. simulans and D. melanogaster, suggesting that the selective forces associated with climate are acting on the same genes and phenotypes in the two species. Expand
Secondary contact and local adaptation contribute to genome‐wide patterns of clinal variation in Drosophila melanogaster
TLDR
The results provide novel insight into the well‐studied system of clinal differentiation in D. melanogaster and provide a context for future studies seeking to identify loci contributing to local adaptation in a wide variety of organisms, including other invasive species as well as temperate endemics. Expand
Drosophila suzukii: The Genetic Footprint of a Recent, Worldwide Invasion
TLDR
The results indicate high levels of nucleotide diversity in this invasive fruit fly species and suggest that the recent invasions of Europe and the continental United States are independent demographic events, which highlights the importance of integrating population structure into demographic models. Expand
Quantitative Trait Loci Affecting Phenotypic Plasticity and the Allometric Relationship of Ovariole Number and Thorax Length in Drosophila melanogaster
TLDR
The genetic correlation between ovariole number and thorax length was positive, but the strength of this correlation decreased with increasing yeast concentration, and genetic variation and genotype-by-environment (G × E) interactions were observed for both traits. Expand
Secondary contact and local adaptation contribute to genome-wide patterns of clinal variation in Drosophila melanogaster
TLDR
It is shown that recently derived North America and Australia populations were likely founded by both European and African lineages and that this admixture event contributed to genome-wide patterns of parallel clinal variation. Expand
Empirical Validation of Pooled Whole Genome Population Re-Sequencing in Drosophila melanogaster
TLDR
It is demonstrated that pooled sequencing provides a faithful estimate of population allele frequency with the error well approximated by binomial sampling, and is a reliable means of novel SNP discovery with low false positive rates. Expand
A highly pleiotropic amino acid polymorphism in the Drosophila insulin receptor contributes to life‐history adaptation
TLDR
The alleles of a complex amino acid insertion–deletion polymorphism in the Drosophila insulin receptor show independent, parallel clines in frequency across the North American and Australian continents, and are associated with predictable differences in these traits, consistent with patterns of Drosophile life‐history variation across geography. Expand
LDx: Estimation of Linkage Disequilibrium from High-Throughput Pooled Resequencing Data
TLDR
LDx, a computational tool for estimating linkage disequilibrium (LD) from pooled resequencing data, is presented and r2 estimates from LDx are demonstrated to be capable of distinguishing alternative demographic models representing plausible demographic histories of D. melanogaster. Expand
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