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Activity of nimesulide on constitutive and inducible cyclooxygenases.
Prostaglandins are pro-inflammatory but are gastroprotective. The gastric mucosa synthesizes prostaglandins mainly via constitutive cyclooxygenase (COX-1), whereas leucocytes have inducible enzymeExpand
Prostaglandins from tumours of human large bowel.
Prostaglandins (PGs) may be important in the growth of tumours (Jaffe, 1974) and their ability to metastasize to bone (Bennett et al., 1975, 1976a, b). Human colon cancer cells in tissue cultureExpand
Nimesulide: an NSAID that preferentially inhibits COX-2, and has various unique pharmacological activities
Nimesulide is a NSAID with good anti-inflammatory, analgesic and antipyretic activities expected of such compounds. However, in addition it has some unique therapeutic and pharmacological activities.Expand
NSAIDs, Cox-2 inhibitors, and the gut
The biological activities of phthalate esters on rat gastric muscle.
Monoethylhexyl phthalate, at concentrations that can occur in blood stored in plastic bags (0.1-0.5 mg/ml), reduced contractions of rat isolated gastric fundus to PGE2 and acetylcholine; the diethylExpand
Release of prostaglandins in ocular inflammation in the rabbit.
VARIOUS studies have suggested that prostaglandins (PGs) may be involved in the ocular response to acute inflammation. PGs are present in ocular tissues1–4 and can reproduce many of theExpand
Prostaglandin-like Activity in Ocular Inflammation
Aqueous humour samples from untreated patients with acute anterior uveitis were found to contain substantial amounts of prostaglandin-like activity. Little activity was found in aqueous from patientsExpand
Relationship of bone destruction in skeletal metastases to osteoclast activation and prostaglandins
TWO principal mechanisms seem to be responsible for the bone destruction associated with skeletal metastases. The earlier and quantitatively most important mechanism seems to be mediated byExpand
METABOLITES OF ARACHIDONIC ACID FORMED BY HUMAN GASTROINTESTINAL TISSUES AND THEIR ACTIONS ON THE MUSCLE LAYERS
1 Gas chromatography‐mass spectrometry demonstrated the presence of arachidonic acid (AA), 6‐keto‐prostaglandin F1α and thromboxane B2 (TxB2) in all extracts of homogenized muscle or mucosa fromExpand
Modulation by prostaglandins of contractions in guinea-pig ileum.
A high concentration of indomethacin (40mu-g/ml) substantially reduced contractions of guinea-pig isolated ileum in Krebs solution to nerve stimulation with electrical pulses or nicotine. ResponsesExpand
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