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Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis.
BACKGROUND There is a scarcity of published data on the global prevalence of obstructive sleep apnoea, a disorder associated with major neurocognitive and cardiovascular sequelae. We used publiclyExpand
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G-protein beta3 subunit gene (GNB3) variant in causation of essential hypertension.
-Essential hypertensives display enhanced signal transduction through pertussis toxin-sensitive G proteins. The T allele of a C825T variant in exon 10 of the G protein beta3 subunit gene (GNB3)Expand
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Linkage and association of tumor necrosis factor receptor 2 locus with hypertension, hypercholesterolemia and plasma shed receptor.
Tumor necrosis factor (TNF) receptor 2 (TNF-R2) has been implicated in insulin resistance and metabolic syndrome disorders, one of which is hypertension (HT). We therefore decided to test markers inExpand
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Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension
Objective: To perform association studies of polymorphisms of the potential candidate essential hypertension (HT) genes GRK4, PTP1B and HSD3B1. Methods: Subjects consisted of 168 unrelated, CaucasianExpand
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Effect of Telemedicine Education and Telemonitoring on Continuous Positive Airway Pressure Adherence. The Tele‐OSA Randomized Trial
Rationale: Automated telemedicine interventions could potentially improve adherence to continuous positive airway pressure (CPAP) therapy. Objectives: Examining the effects of telemedicine‐deliveredExpand
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Haplotype analysis of aldosterone synthase gene (CYP11B2) polymorphisms shows association with essential hypertension
Objective The CYP11B2 locus is an important candidate region in essential hypertension (HT). We therefore investigated CYP11B2 polymorphisms T−344C, T4986C and A6547G for association with essentialExpand
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Association analyses of endothelial nitric oxide synthase gene polymorphisms in essential hypertension.
Endothelial nitric oxide synthase (eNOS), encoded by NOS3, is a potent regulator of vasomotor tone and peripheral resistance. Congenic experiments indicate that a chromosomal segment containing theExpand
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Tumor necrosis factor receptor 2 gene (TNFRSF1B) in genetic basis of coronary artery disease
Tumor necrosis factor (TNF)-α has been implicated in pathophysiological processes in coronary artery disease (CAD). TNF receptor 2 is of particular interest in mediating such effects. The gene forExpand
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Association of EDNRA, but not WNK4 or FKBP1B, polymorphisms with essential hypertension
In a study of the genetic basis of essential hypertension (HT), we tested four variants in three candidate genes not previously investigated in HT. These encoded the endothelin receptor type AExpand
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No association of Angiotensin-Converting enzyme 2 gene (ACE2) polymorphisms with essential hypertension☆
Abstract Recent intriguing findings from genetic linkage, knockout, and physiologic studies in mice and rats led us to conduct the first investigation of the novel angiotensin-converting enzymeExpand
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