• Publications
  • Influence
Thymic stromal lymphopoietin–elicited basophil responses promote eosinophilic esophagitis
Eosinophilic esophagitis (EoE) is a food allergy–associated inflammatory disease characterized by esophageal eosinophilia. Current management strategies for EoE are nonspecific, and thus there is aExpand
  • 258
  • 11
  • Open Access
Pediatric eosinophilic esophagitis is associated with changes in esophageal microRNAs.
The incidence of eosinophilic esophagitis (EoE) has increased in the past several years, yet our understanding of its pathogenesis remains limited. To test the hypothesis that microRNAs (miRNAs) areExpand
  • 9
  • 3
  • Open Access
Inflammation-associated microbiota in pediatric eosinophilic esophagitis
BackgroundEosinophilic esophagitis (EoE) is an allergic disorder characterized by eosinophil-predominant esophageal inflammation, which can be ameliorated by food antigen restriction. Though recentExpand
  • 71
  • 2
  • Open Access
Esophageal epithelial and mesenchymal cross-talk leads to features of epithelial to mesenchymal transition in vitro.
BACKGROUND Esophageal fibrosis is a complication of eosinophilic esophagitis (EoE) which has been attributed to both subepithelial fibrosis and to epithelial to mesenchymal transition (EMT), aExpand
  • 43
  • 2
Influence of Age and Eosinophilic Esophagitis on Esophageal Distensibility in a Pediatric Cohort
Objectives:Sequelae of eosinophilic esophagitis (EoE) include food impaction and esophageal stricture. Duration of inflammation is a predicted risk factor; however, complications remainExpand
  • 38
  • 2
  • Open Access
Thymic stromal lymphopoietin-mediated extramedullary hematopoiesis promotes allergic inflammation.
Extramedullary hematopoiesis (EMH) refers to the differentiation of hematopoietic stem cells (HSCs) into effector cells that occurs in compartments outside of the bone marrow. Previous studies linkedExpand
  • 53
  • 1
ATG7 Gene Expression as a Novel Tissue Biomarker in Eosinophilic Esophagitis
9. Beaugerie L , Svrcek M , Seksik P et al. Risk of colorectal high-grade dysplasia and cancer in a prospective observational cohort of patients with infl ammatory bowel disease . GastroenterologyExpand
  • 9
  • 1
The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial Changes
Background & Aims Aberrations in the esophageal proliferation-differentiation gradient are histologic hallmarks in eosinophilic esophagitis (EoE) and gastroesophageal reflux disease. A reliableExpand
  • 20
Esophageal epithelial cells acquire functional characteristics of activated myofibroblasts after undergoing an epithelial to mesenchymal transition.
BACKGROUND AND AIMS Eosinophilic esophagitis (EoE) is an allergic inflammatory disease that leads to esophageal fibrosis and stricture. We have recently shown that in EoE, esophageal epithelial cellsExpand
  • 22
Eosinophilic Esophagitis-Associated Chemical and Mechanical Microenvironment Shapes Esophageal Fibroblast Behavior
Objectives: Eosinophilic esophagitis (EoE) is an immune-mediated allergic disease characterized by progressive esophageal dysmotility and fibrotic stricture associated with chronic esophagealExpand
  • 19