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Drug-induced liver injury: recent advances in diagnosis and risk assessment
Idiosyncratic drug-induced liver injury (IDILI) is a rare but potentially severe adverse drug reaction that should be considered in patients who develop laboratory criteria for liver injury secondary… Expand
Lipid Lowering Therapy with Fluvastatin and Pravastatin in Patients with HIV Infection and Antiretroviral Therapy: Comparison of Efficacy and Interaction with Indinavir
Abstract.Background:Lipoprotein disorders in HIV-positive patients receiving highly active antiretroviral therapy (HAART) are becoming a major concern in HIV treatment, since there is growing… Expand
Plasma cystatin C is a predictor of renal dysfunction, acute‐on‐chronic liver failure, and mortality in patients with acutely decompensated liver cirrhosis
The development of acute‐on‐chronic liver failure (ACLF) in patients with liver cirrhosis is associated with high mortality rates. Renal failure is the most significant organ dysfunction that occurs… Expand
Monocyte-derived hepatocyte-like cells for causality assessment of idiosyncratic drug-induced liver injury
Background Idiosyncratic drug-induced liver injury (iDILI) is a frequent cause of acute liver injury and a serious problem in late stage drug-development. Its diagnosis is one of the most challenging… Expand
Serum Neutrophil Gelatinase-Associated Lipocalin – A Sensitive Novel Marker of Renal Impairment in Liver Cirrhosis?
Recently, neutrophil gelatinase-associated lipocalin (NGAL) has been introduced as a sensitive and early marker of acute kidney injury  . NGAL in cirrhosis and chronic renal failure has not been… Expand
Drug-Induced Liver Injury and Individual Cell Models
Drug-induced liver injury (DILI) is the most common cause of acute liver failure and accounts for the majority of regulatory actions on drugs. Furthermore, DILI is a relevant cause for project… Expand
Development and Validation of a Test to Identify Drugs That Cause Idiosyncratic Drug‐Induced Liver Injury
- A. Benesic, Isabelle Rotter, D. Dragoi, S. Weber, Marie-Luise Buchholtz, A. Gerbes
- Clinical gastroenterology and hepatology : the…
- 1 September 2018
Background & Aims Idiosyncratic drug‐induced liver injury (iDILI) is one of the most challenging diagnoses in hepatology. It is frequently impossible to identify the agent that has caused iDILI in… Expand
Proteomics Analysis of Monocyte-Derived Hepatocyte-Like Cells Identifies Integrin Beta 3 as a Specific Biomarker for Drug-Induced Liver Injury by Diclofenac
- Diana Dragoi, A. Benesic, G. Pichler, N. A. Kulak, H. Bartsch, A. Gerbes
- Front. Pharmacol.
- 4 July 2018
Idiosyncratic drug-induced liver injury (iDILI) is a major cause of acute liver failure resulting in liver transplantation or death. Prediction and diagnosis of iDILI remain a great challenge, as… Expand
Liquid chromatographic method for the determination of uridine in human serum.
- M. Zilly, P. Langmann, +4 authors H. Klinker
- Chemistry, Medicine
- Journal of chromatography. B, Analytical…
- 25 April 2004
To evaluate uridine levels in humans we developed a very sensitive and specific high-performance liquid chromatographic method for the determination of uridine in serum. We use techniques which are… Expand
Drug-Drug Combinations can Enhance Toxicity as shown by Monocyte-Derived Hepatocyte-like Cells from Patients with Idiosyncratic Drug-Induced Liver Injury.
- A. Benesic, Kowcee Jalal, A. Gerbes
- Biology, Medicine
- Toxicological sciences : an official journal of…
- 1 October 2019
BACKGROUND Drug-induced liver injury (DILI) is a major cause for acute liver failure and regulatory actions on novel drugs. Individual patient characteristics are the main determinant of… Expand