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Use of TTC staining for the evaluation of tissue injury in the early phases of reperfusion after focal cerebral ischemia in rats
Single dose of MDMA causes extensive decrement of serotoninergic fibre density without blockage of the fast axonal transport in Dark Agouti rat brain and spinal cord
The results suggest that a single dose of MDMA elicits widespread depletion of TpH and 5‐HTT immunoreactivity in serotoninergic axons without morphological sign of the blockage of the fast anterograde axonal transport, and does not support the notion of MDMA‐induced axotomy of serotoninergic neurones.
Neuroprotective and anticonvulsant effects of EGIS‐8332, a non‐competitive AMPA receptor antagonist, in a range of animal models
The present study evaluated the neuroprotective and anticonvulsant effects of EGIS‐8332, a non‐competitive AMPA receptor antagonist, as a potential drug candidate.
Therapeutic time window of neuroprotection by non-competitive AMPA antagonists in transient and permanent focal cerebral ischemia in rats
Decreased vasoconstrictor responses in remote cerebral arteries after focal brain ischemia and reperfusion in the rat, in vitro.
Analysis of the early phase of ischemic-reperfusion brain damage using histological, neurochemical and functional methods
- A. Benedek
- Biology, Medicine
To study how precisely the ischaemic-reperfusion damage (IR) is reflected by the methods routinely applied in the preclinical practice, rats underwent in vivo assessment applying 4 different neurological scales.