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Quantitative Proteomics Analysis of the Secretory Pathway
TLDR
The data support a role for COPI vesicles in recycling and cisternal maturation, showing that Golgi-resident proteins are present at a higher concentration than secretory cargo. Expand
SSR alpha and associated calnexin are major calcium binding proteins of the endoplasmic reticulum membrane.
TLDR
It is proposed that the function of the complex purified as a complex with two nonphosphorylated membrane glycoproteins is to regulate Ca(2+)-dependent retention mechanisms for luminal proteins of the endoplasmic reticulum. Expand
Characterization of an RNA Granule from Developing Brain *S
TLDR
The studies define the isolation and composition of RNA granules expressed in developing brain and show that brain-derived neurotrophic factor, but not activity, increased the proportion of moving granules. Expand
TUC-4b, a Novel TUC Family Variant, Regulates Neurite Outgrowth and Associates with Vesicles in the Growth Cone
TLDR
Data suggest that TUC-4b can regulate neurite extension and branching through a mechanism that may involve membrane transport in the growth cone, suggesting a potential role in growth cone vesicle transport. Expand
Tandem MS analysis of brain clathrin-coated vesicles reveals their critical involvement in synaptic vesicle recycling.
TLDR
Thirty-two proteins representing many of the known components of synaptic vesicles (SVs) were identified, supporting that a main function for brain CCVs is to recapture SVs after exocytosis and a single-step model for SV sorting during CCV-mediated recycling of SVs is supported. Expand
A family of related ATP-binding subunits coupled to many distinct biological processes in bacteria
TLDR
A class of closely related ATP-binding proteins, from several bacterial species, which are associated with a variety of cellular functions including membrane transport, cell division, nodulation in Rhizobium and haemolysin export are described. Expand
A HUPO test sample study reveals common problems in mass spectrometry-based proteomics
TLDR
Central analysis determined missed identifications, environmental contamination, database matching and curation of protein identifications as sources of problems in liquid chromatography–mass spectrometry–based proteomics. Expand
Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics.
TLDR
The utility of proteomics in the identification of novel vesicle trafficking proteins is revealed as the rat homologue of a predicted gene product from human, mouse, and Drosophila genomics projects, which is named enthoprotin. Expand
High-resolution crystal structure of Arthrobacter aurescens chondroitin AC lyase: an enzyme-substrate complex defines the catalytic mechanism.
TLDR
Comparison of this structure with that of chondroitinase AC from Flavobacterium heparinum (FlavoAC) provides an explanation for the exolytic and endolytic mode of action of ArthroAC and FlavoAC, respectively. Expand
An amino-terminal fragment of urokinase isolated from a prostate cancer cell line (PC-3) is mitogenic for osteoblast-like cells.
TLDR
These studies demonstrate the production of a mitogenic NH2-terminal fragment of uPA by a human prostatic cancer cell line which may be of importance in the pathogenesis of osteoblastic metastases. Expand
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