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Effect of chromium picolinate on insulin sensitivity in vivo
TLDR
Investigation of the effect of chromium (Cr) supplementation on insulin sensitivity and body composition in obese subjects with a family history of Type 2 diabetes suggests that Cr may alter insulin sensitivity independent of a change in weight or body fat percentage. Expand
Caloric restriction and cardiovascular aging in cynomolgus monkeys (Macaca fascicularis): metabolic, physiologic, and atherosclerotic measures from a 4-year intervention trial.
TLDR
It is demonstrated that CR significantly improves insulin sensitivity, but when elevated plasma cholesterol concentrations were held similar, there was no effect on atherosclerosis extent. Expand
Caloric restriction decreases age-dependent accumulation of the glycoxidation products, N epsilon-(carboxymethyl)lysine and pentosidine, in rat skin collagen.
TLDR
It is concluded that CR reduces the extent of glycation of blood and tissue proteins and the age-related accumulation of glycoxidation products in skin collagen. Expand
Effect of age and caloric restriction on insulin receptor binding and glucose transporter levels in aging rats
TLDR
The data indicates that caloric restriction may have tissue-specific effects for insulin receptor binding, and that the improved insulin sensitivity in CR states is not a result of altered glucose transporter protein content. Expand
Contribution of visceral fat mass to the insulin resistance of aging.
TLDR
The purpose of this study was to explore the association of IAF with age and insulin sensitivity (SI) after controlling for obesity and quantified total and subcutaneous abdominal fat and IAF at the umbilicus using a validated MRI scanning technique. Expand
Glycohemoglobin measured by automated affinity HPLC correlates with both short-term and long-term antecedent glycemia.
TLDR
GHb, traditionally considered a marker for only long-term diabetic control, correlated significantly with both short-term and long- term antecedent glycemia in 70 diabetic subjects, despite weekly changes in mean blood glucose in the subjects who received more intensive intervention. Expand
Clinical validation of a second-generation fructosamine assay.
TLDR
The validity of the second-generation fructosamine assay to assess short-term glycemic control in 23 non-insulin-dependent diabetic patients who participated for 10 weeks in an intensive intervention program designed to rapidly normalize the clinical glycemic profile is evaluated. Expand
Determination of furosine in biomedical samples employing an improved hydrolysis and high-performance liquid chromatographic technique.
TLDR
Furosine generated from acid hydrolysis of purified hepatic membranes in a diabetic and non-diabetic animal model agreed with traditional methods assessing total glycated protein (i.e., boronate affinity methods). Expand
Influence of caloric restriction on the development of atherosclerosis in nonhuman primates: progress to date.
TLDR
Results from 4 years of intervention demonstrate that CR improves cardiovascular risk factors (such as visceral fat accumulation) and improves insulin sensitivity, and preliminary analysis of atherosclerotic lesion extent in the abdominal aorta has failed to demonstrate differences between control animals and CR animals. Expand
Increased nonenzymatically glycosylated proteins in the vitreous humor of diabetic animals.
TLDR
Results indicate that glycation is increased in the vitreous humor of short-term diabetic animals, and therefore may be one of the initial triggers for clinically apparent diabetic retinopathy. Expand
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