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Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons.
The triglycerides in chylomicrons are hydrolyzed by lipoprotein lipase (LpL) along the luminal surface of the capillaries. However, the endothelial cell molecule that facilitates chylomicronExpand
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GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries.
The lipolytic processing of triglyceride-rich lipoproteins by lipoprotein lipase (LPL) is the central event in plasma lipid metabolism, providing lipids for storage in adipose tissue and fuel forExpand
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The Acute Phase Response Is Associated with Retinoid X Receptor Repression in Rodent Liver*
The acute phase response (APR) is associated with decreased hepatic expression of many proteins involved in lipid metabolism. The nuclear hormone receptors peroxisome proliferator-activated receptorExpand
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Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response.
Expression of P-450 (Cyp) enzymes is reduced in liver during the acute phase response, contributing to the decrease in bile acid levels and drug metabolism during infection. Nuclear hormone receptorsExpand
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Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA
Lamins A and C, alternatively spliced products of the LMNA gene, are key components of the nuclear lamina. The two isoforms are found in similar amounts in most tissues, but we observed an unexpectedExpand
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AGPAT6 Is a Novel Microsomal Glycerol-3-phosphate Acyltransferase*
  • Y. Chen, M. Kuo, +13 authors G. Cao
  • Medicine, Biology
  • Journal of Biological Chemistry
  • 11 April 2008
AGPAT6 is a member of the 1-acylglycerol-3-phosphate O-acyltransferase (AGPAT) family that appears to be important in triglyceride biosynthesis in several tissues, but the precise biochemicalExpand
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Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes.
  • J. I. Toth, S. Yang, +6 authors L. Fong
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 6 September 2005
Defects in the biogenesis of lamin A from its farnesylated precursor, prelamin A, lead to the accumulation of prelamin A at the nuclear envelope, cause misshapen nuclei, and result in progeroidExpand
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Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.
Isoprenylcysteine carboxyl methyltransferase (Icmt) methylates the carboxyl-terminal isoprenylcysteine of CAAX proteins (e.g., Ras and Rho proteins). In the case of the Ras proteins, carboxylExpand
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Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesitys⃞s⃞ The online version of this article (available at http://www.jlr.org) contains additional table and figure. Published,
Triglyceride synthesis in most mammalian tissues involves the sequential addition of fatty acids to a glycerol backbone, with unique enzymes required to catalyze each acylation step. Acylation at theExpand
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The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries.
Triglyceride-rich lipoproteins (TRLs) undergo lipolysis by lipoprotein lipase (LPL), an enzyme that is transported to the capillary lumen by an endothelial cell protein, GPIHBP1. For LPL-mediatedExpand
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