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Review of community prevalence of depression in later life.
A systematic review of community-based studies of the prevalence of depression in later life (55+) found that major depression is relatively rare among the elderly, minor depression is more common, while all depressive syndromes deemed clinically relevant yield an average prevalence of 13.5%. Expand
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
A genome-wide association meta-analysis of individuals with clinically assessed or self-reported depression identifies 44 independent and significant loci and finds important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia. Expand
Anxiety disorders in later life: a report from the longitudinal aging study Amsterdam
The prevalence and risk factors of anxiety disorders in the older (55–85) population of The Netherlands are studied to find out if older people are more likely to suffer from anxiety disorders. Expand
The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods
The Netherlands Study of Depression and Anxiety (NESDA) is a multi‐site naturalistic cohort study to: (1) describe the long‐term course and consequences of depressive and anxiety disorders, and (2)Expand
Prevalence and risk indicators of depression in elderly nursing home patients: the AGED study.
The prevalence of depression in the nursing home population is very high, and the prevalence rates found were three to four times higher than in the community-dwelling elderly. Expand
Anxiety and depression in later life: Co-occurrence and communality of risk factors.
Although high levels of comorbidity between major depressive Disorder and anxiety disorders were found, comparing risk factors associated with pure major depressive disorder and pure anxiety disorders revealed more differences than similarities. Expand
Major and minor depression in later life: a study of prevalence and risk factors.
It appears that major depression is more often an exacerbation of a chronic mood disturbance, with roots in long-standing vulnerability factors; while minor depression isMore often a reaction to the stresses commonly experienced in later life. Expand
Duration of major depressive episodes in the general population: Results from the Netherlands Mental Health Survey and Incidence Study (NEMESIS)
Although half of those affected with MDE recovered rapidly, the risk of chronicity (duration 24months or more) was considerable and underlines the necessity of diagnosing and treating those at risk. Expand
Depression in Europe. Geographical distribution among older people.
Considerable variation occurs in the levels of depression across Europe, the cause for which is not immediately obvious, and case and sub-case levels taken together show greater variability, suggesting that it is not a matter of case/sub-case selection criteria, which were standardised by computer. Expand
Development of the EURO-D scale--a European, Union initiative to compare symptoms of depression in 14 European centres.
The EURO-D scale should permit valid comparison of risk-factor associations between centres, even if between-centre variation remains difficult to attribute. Expand