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Practical pharmaceutical chemistry
Practical pharmaceutical chemistry , Practical pharmaceutical chemistry , کتابخانه دیجیتال جندی شاپور اهواز
Urinary excretion kinetics of amphetamine in man
TLDR
The urinary excretion of amphetamine has been examined in 11 male subjects after oral administration of (+)‐ and (–)‐ amphetamine sulphate and it was shown to be dependent upon urinary pH. Expand
SYNTHETIC ANALGESICS: STEREOCHEMICAL CONSIDERATIONS
  • A. Beckett, A. Casy
  • Chemistry, Medicine
  • The Journal of pharmacy and pharmacology
  • 1 September 1954
TLDR
Active analgesics are shown to have structures which enable them to present similar surfaces to allow of their association with a proposed “analgesic receptor surface,” the essential features of which are described. Expand
A possible relation between pKa1 and lipid solubility and the amounts excreted in urine of some tobacco alkaloids given to man
TLDR
Correlations of pKa1 and lipid solubility and the urinary excretion of these compounds were made and more nornicotine and anabasine than their corresponding tertiary amines nicotine and methylanabAsine were excreted unchanged in the urine. Expand
Alkaloids from Mitragyna speciosa (Korth.)
TLDR
The picrate mother liquors yielded ajmalicine, an isomer of mitragynine named speciogynine, a 9-methoxy derivative of corynantheine-like structure named puynanrheine and unidentified alkaloids and the ether-insoluble bases yielded mainly mitraphylline. Expand
The biotransformation of methadone in man: Synthesis and identification of a major metabolite
After administration of methadone to man, only two basic urinary excretion products were detected, these were unchanged drug and 2‐ethyl‐1, 5‐dimethyl‐3, 3‐diphenyl‐1‐pyrroline. The hydriodide of theExpand
The relation between blood levels and urinary excretion of amphetamine under controlled acidic and under fluctuating urinary pH values using [14C]amphetamine
TLDR
The apparent rate of urinary excretion of amphetamine was proportional to its plasma concentration only under the controlled acidic urinary conditions, and when urinary pH fluctuated, clearance of the drug could be accounted for by this route. Expand
THE ACTIVE CONSTITUENTS OF RASPBERRY LEAVES
1 A method for the preparation of active extracts from raspberry leaves is described. 2 Aqueous extracts have been shown to contain a number of active constituents including a smooth muscleExpand
Urinary Excretion of Methylamphetamine in Man
IT has been reported that, after the administration of N-methylamphetamine in man, substantial amounts of the unchanged drug and some amphetamine are excreted in the urine1, but detailed results haveExpand
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