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The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.
This review represents an update of the nomenclature system for the UDP glucuronosyltransferase gene superfamily, which is based on divergent evolution and is anticipated that this UGT gene nomenClature system will require updating on a regular basis.
Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging.
- F. Labrie, A. Bélanger, L. Cusan, J. Goméz, B. Candas
- Biology, MedicineJournal of Clinical Endocrinology and Metabolism
- 1 August 1997
A marked decline in circulating adrenal C19 steroids and their resulting androgen metabolites takes place between the age groups of 20- to 30-yr olds and 50- to 60-yr-olds, with smaller changes observed after the age of 60 yr, suggesting a parallel decrease in the total androgen pool with age.
Is dehydroepiandrosterone a hormone?
The new field of intracrinology or local formation of sex steroids from DHEA in target tissues has permitted major advances in the treatment of the two most frequent cancers, namely breast and prostate cancer, while its potential use as a physiological HRT could well provide a physiological balance of androgens and estrogens, thus offering exciting possibilities for women's health at menopause.
Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members.
- D. Turgeon, J. Carrier, E. Lévesque, D. Hum, A. Bélanger
- Biology, ChemistryEndocrinology
- 1 February 2001
The relative activities and the major substrates of human steroid-metabolizing UGT2B enzymes, which are expressed in a wide variety of steroid target tissues, are clearly demonstrated.
Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone.
DHEA has been found to increase bone mineral density and to stimulate vaginal maturation without affecting the endometrium, while improving well-being and libido with no significant side effects and thus minimizing the potential side effects observed with androgens or estrogens administered systemically.
Androgen biosynthetic pathways in the human prostate.
Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans
3'-azido-3'-deoxythimidine (AZT) is glucuronidated by human UDP-glucuronosyltransferase 2B7 (UGT2B7).
The glucuronidation of AZT by UGT2B7, which is a UGT 2B protein expressed in the liver, is consistent with previous findings and supports the physiological relevance of this enzyme in AZT conjugation.
Isolation and characterization of UGT2B15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene.
- E. Lévesque, M. Beaulieu, M. Green, T. Tephly, A. Bélanger, D. Hum
- 1 August 1997
Specific reverse transcriptase (RT)-PCR analysis revealed expression of the UGT2B15 gene in a wide range of extrahepatic tissues including the human liver, kidney, testis, mammary gland, placenta, adipose, skin, uterus, prostate and lung, indicating that it is a major glucuronidation enzyme in humans.
Intracrinology: role of the family of 17 beta-hydroxysteroid dehydrogenases in human physiology and disease.
The last and key step in the formation of all estrogens and androgens is catalyzed by members of the family of 17beta-hydroxysteroid dehydrogenases (17 beta-HSDs), which provide each cell with the means of precisely controlling the intracellular concentration of each sex steroid according to local needs.