• Publications
  • Influence
The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.
TLDR
This review represents an update of the nomenclature system for the UDP glucuronosyltransferase gene superfamily, which is based on divergent evolution and is anticipated that this UGT gene nomenClature system will require updating on a regular basis. Expand
Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging.
TLDR
A marked decline in circulating adrenal C19 steroids and their resulting androgen metabolites takes place between the age groups of 20- to 30-yr olds and 50- to 60-yr-olds, with smaller changes observed after the age of 60 yr, suggesting a parallel decrease in the total androgen pool with age. Expand
Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members.
TLDR
The relative activities and the major substrates of human steroid-metabolizing UGT2B enzymes, which are expressed in a wide variety of steroid target tissues, are clearly demonstrated. Expand
Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone.
TLDR
DHEA has been found to increase bone mineral density and to stimulate vaginal maturation without affecting the endometrium, while improving well-being and libido with no significant side effects and thus minimizing the potential side effects observed with androgens or estrogens administered systemically. Expand
Is dehydroepiandrosterone a hormone?
TLDR
The new field of intracrinology or local formation of sex steroids from DHEA in target tissues has permitted major advances in the treatment of the two most frequent cancers, namely breast and prostate cancer, while its potential use as a physiological HRT could well provide a physiological balance of androgens and estrogens, thus offering exciting possibilities for women's health at menopause. Expand
Androgen biosynthetic pathways in the human prostate.
TLDR
The present chapter reviews the literature obtained from various human, dog, rat and mouse prostate tissues, as well as primary cells and prostatic cancer cell lines, to provide a clearer picture of the pathways involved in DHT biosynthesis and metabolism in the human prostate. Expand
Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans
TLDR
It is postulated that the conjugating activity of UGT enzymes is the main mechanism for modulating the action of steroids and protecting the androgen-sensitive tissues from deleteriously high concentrations of DHT, ADT and 3alpha-DIOL. Expand
3'-azido-3'-deoxythimidine (AZT) is glucuronidated by human UDP-glucuronosyltransferase 2B7 (UGT2B7).
TLDR
The glucuronidation of AZT by UGT2B7, which is a UGT 2B protein expressed in the liver, is consistent with previous findings and supports the physiological relevance of this enzyme in AZT conjugation. Expand
Intracrinology: role of the family of 17 beta-hydroxysteroid dehydrogenases in human physiology and disease.
TLDR
The last and key step in the formation of all estrogens and androgens is catalyzed by members of the family of 17beta-hydroxysteroid dehydrogenases (17 beta-HSDs), which provide each cell with the means of precisely controlling the intracellular concentration of each sex steroid according to local needs. Expand
Androgen glucuronides, instead of testosterone, as the new markers of androgenic activity in women
TLDR
The present data show that measurement of the total pool of androgens reflected by the serum levels of ADT-G and 3alpha-diol-G cannot be replaced by serum testosterone or any other steroid, including DHEA or D HEA sulphate. Expand
...
1
2
3
4
5
...