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Lethal factors and enzymes in the secretion from Duvernoy's gland of three colubrid snakes.
TLDR
At least two of the snake species examined have toxic secretions that may be important during feeding by killing or weakening and helping to subdue the struggling prey.
Accumulation of some secretory enzymes in venom glands of Vipera palaestinae.
TLDR
It is concluded that each of the enzymes is secreted at a rate independent of the other two; this pattern of secretion can best be described as nonparallel.
Sarafotoxins S6: several isotoxins from Atractaspis engaddensis (burrowing asp) venom that affect the heart.
TLDR
Three isotoxins, named sarafotoxins S6a1, S6b and S6c, with strong cardiotoxic activity were isolated from the venom of a snake, Atractaspis engaddensis, and their structure and activity are novel among snake venom components.
A novel cardiotoxic polypeptide from the venom of Atractaspis engaddensis (burrowing asp): cardiac effects in mice and isolated rat and human heart preparations.
TLDR
Studies with rat and human isolated heart preparations showed that the toxin exerts a powerful coronary vasoconstriction (rats), and positive inotropic effects (rats and humans).
Evolution of the sarafotoxin/endothelin superfamily of proteins.
TLDR
Analysis of the resulting phylogenetic trees revealed that in several lineages, the peptides have independently accumulated identical replacements in position 2, therefore supporting the hypothesis that residue 2 is crucial to their activity.
Sarafotoxins and endothelins: evolution, structure and function.
TLDR
This review covers recent advances in the study of the chemical and biological properties of the sarafotoxins and endothelins.
The evolutionary history of the sarafotoxin/endothelin/endothelin-like superfamily.
TLDR
In several lineages, the peptides have independently accumulated identical amino acid replacements in position 2, which supports the hypothesis that residue 2 is crucial to biological activity.
Gel permeation patterns of venoms from eleven species of the genus Vipera.
TLDR
Gel filtration of venoms from eleven species of the genus Vipera shows similar patterns on Sephadex G-75, with three groups of protein peaks, with synergism between phospholipase A and other fractions that considerably increases lethal potency.
Functional endothelin/sarafotoxin receptors in the rat uterus.
TLDR
It is suggested that the functional ET/SRTX receptor of the rat uterus that is coupled to PI hydrolysis may be of physiological significance.
SRTX‐d, a new native peptide of the endothelin/sarafotoxin family
Sarafotoxin; Endothelin; Snake venom; Aorta
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