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Sarafotoxin, a novel vasoconstrictor peptide: phosphoinositide hydrolysis in rat heart and brain.
Sarafotoxins, a group of 21-residue cardiotoxic peptides from snake venom that induce coronary vasoconstriction, show high-affinity binding to rat atrial and brain membranes and activate theExpand
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Endothelins are more sensitive than sarafotoxins to neutral endopeptidase: possible physiological significance.
Incubation of endothelins (ETs) with bovine kidney neutral endopeptidase (NEP) resulted in a selective two-step degradation with loss of biochemical activity. The Km of the enzyme indicatedExpand
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REGULATION OF PROTEIN SYNTHESIS IN THE VENOM GLAND OF VIPERID SNAKES
Morphological changes in the venom gland of V. ammodytes were studied after the removal of the venom from the gland lumina (milking) It was found that the height of the secretory cells was changedExpand
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Positive Darwinian selection in Vipera palaestinae phospholipase A2 genes is unexpectedly limited to the third exon.
The venom of Vipera palaestinae contains a two-component toxin, consisting of an acidic phospholipase A2 (PLA2) and a basic protein. Here we report the cloning and sequence analysis of the completeExpand
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Lethal factors and enzymes in the secretion from Duvernoy's gland of three colubrid snakes.
Secretion from Duvernoy's gland of the colubrid snakes Malpolon, Spalerosophis, and Thamnophis was obtained by pilocarpine stimulation and tested for lethality and selected enzymatic activities.Expand
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Asynchrony in the synthesis of secretory proteins in the venom gland of the snake Vipera palaestinae.
1. Venom of Vipera palastinae was subjected to isoelectrofocusing on polyacrylamide gel. The protein separation profiles were similar for different venom samples; more than 25 protein bands with aExpand
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Accumulation of some secretory enzymes in venom glands of Vipera palaestinae.
Secretion of venom in the venom glands of Vipera palaestinae was studied by measuring the protein content and enzymatic activities of L-amino acid oxidase (LAO), phosphodiesterase (PDE), andExpand
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VENOM GLANDS, VENOM SYNTHESIS, VENOM SECRETION AND EVOLUTION
ABSTRACT This paper reviews the embryonic development, structure and function of the compound oral glands of non-venomous and venomous snakes in comparison with other exocrine glands, mainly theExpand
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THE FUNCTION OF 3'5' CYCLIC AMP IN ENZYME SECRETION.
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Sarafotoxins S6: several isotoxins from Atractaspis engaddensis (burrowing asp) venom that affect the heart.
Three isotoxins, named sarafotoxins S6a1, S6b and S6c, with strong cardiotoxic activity were isolated from the venom of a snake, Atractaspis engaddensis. All three sarafotoxins are homologousExpand
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