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A new plasmidic cefotaximase in a clinical isolate of Escherichia coli
The cefotaximase of E. coli GRI represents a new plasmidic (plasmid pMVP-3) broad spectrum β-lactamase (CTX-M) which may not be closely related to either the TEM- oder SHV-family of extended broad spectrumβ- lactamases.
Comparison of the antibacterial activities of the quinolones Bay 12-8039, gatifloxacin (AM 1155), trovafloxacin, clinafloxacin, levofloxacin and ciprofloxacin.
- A. Bauernfeind
- Biology, MedicineThe Journal of antimicrobial chemotherapy
- 1 November 1997
Against gram-positive cocci, the only agents that were more active than ciprofloxacin were those carrying an azabicyclo (trovafloxacIn, Bay 12-8039), 3-amino-pyrrolidinyl (clinafloxACin) or 3-methyl-piperazinyl (gatiflOxacin) moiety at position C7.
Sequences of beta-lactamase genes encoding CTX-M-1 (MEN-1) and CTX-M-2 and relationship of their amino acid sequences with those of other beta-lactamases
- A. Bauernfeind, I. Stemplinger, R. Jungwirth, S. Ernst, J. Casellas
- Biology, ChemistryAntimicrobial agents and chemotherapy
- 1 February 1996
The cefotaximases CTX-M-1/MEN-1 and CTX -M-2 represent two members of a new subgroup of plasmidic class A beta-lactamases.
Cefotaxime-Resistant EnterobacteriaceaeIsolates from a Hospital in Warsaw, Poland: Identification of a New CTX-M-3 Cefotaxime-Hydrolyzing β-Lactamase That Is Closely Related to the CTX-M-1/MEN-1…
- M. Gniadkowski, I. Schneider, Andrzej Pal/ucha, R. Jungwirth, B. Mikiewicz, A. Bauernfeind
- Biology, MedicineAntimicrobial Agents and Chemotherapy
- 1 April 1998
The results suggest that CTX-M genes have been spread among different species of the familyEnterobacteriaceae in the hospital and that the CTx-M-3-expressing C. freundii strain causing routine urinary tract infections has been maintained for a relatively long time in thehospital environment.
Decrease in nosocomial pneumonia in ventilated patients by selective oropharyngeal decontamination (SOD)
The use of SOD significantly reduced the colonization and pneumonia and the total charge for antibiotics and the development of resistance was not observed.
A Novel Type of AmpC β-Lactamase, ACC-1, Produced by a Klebsiella pneumoniae Strain Causing Nosocomial Pneumonia
- A. Bauernfeind, I. Schneider, R. Jungwirth, H. Sahly, U. Ullmann
- BiologyAntimicrobial Agents and Chemotherapy
- 1 August 1999
A Klebsiella pneumoniae strain resistant to oxyimino cephalosporins was cultured from respiratory secretions of a patient suffering from nosocomial pneumonia in Kiel, Germany, in 1997 and represents a new type of AmpC-class enzyme, for which the designation ACC-1 (Ambler class C-1) is proposed.
Comparative characterization of the cephamycinase blaCMY-1 gene and its relationship with other beta-lactamase genes
- A. Bauernfeind, I. Stemplinger, R. Jungwirth, R. Wilhelm, Y. Chong
- BiologyAntimicrobial agents and chemotherapy
- 1 August 1996
The results indicate that the relationship of CMY-1 is closest to MOX-1 among the plasmidic cephamycinases and to AmpC of Pseudomonas aeruginosa among the chromosomal cephalosporinases.
Placebo‐controlled, double‐blind, randomized study of aerosolized tobramycin for early treatment of Pseudomonas aeruginosa colonization in cystic fibrosis
In chronic Pseudomonas aeruginosa pulmonary infection of patients with cystic fibrosis (CF), antibiotic therapy generally fails to eradicate the bacterial pathogen. The mucoid bacterial phenotype,…
Extended broad spectrum β-lactamase in Klebsiella pneumoniae including resistance to cephamycins
The new cephamycinase (CMY-1) was more strongly inhibited by sulbactam in the majority of combinations than by clavulanic acid or tazobactam and should be used as well when screening for super extended broad spectrum (SEBS-) beta-lactamases.
Discrimination of Burkholderia multivorans and Burkholderia vietnamiensis fromBurkholderia cepacia Genomovars I, III, and IV by PCR
- A. Bauernfeind, I. Schneider, R. Jungwirth, Carsten Roller
- BiologyJournal of Clinical Microbiology
- 1 May 1999
In comparison with the polyphasic taxonomic analyses presently necessary for species and genomovar identification within the B. cepacia complex, the procedure is more rapid and easier to perform and may contribute to clarifying the clinical significance of individual members of the complex in cystic fibrosis.