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Functional organization of the yeast proteome by systematic analysis of protein complexes
Most cellular processes are carried out by multiprotein complexes. The identification and analysis of their components provides insight into how the ensemble of expressed proteins (proteome) isExpand
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Proteome survey reveals modularity of the yeast cell machinery
Protein complexes are key molecular entities that integrate multiple gene products to perform cellular functions. Here we report the first genome-wide screen for complexes in an organism, buddingExpand
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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
The stability of the Wnt pathway transcription factor β-catenin is tightly regulated by the multi-subunit destruction complex. Deregulated Wnt pathway activity has been implicated in many cancers,Expand
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β‐catenin is a target for the ubiquitin–proteasome pathway
β‐catenin is a central component of the cadherin cell adhesion complex and plays an essential role in the Wingless/Wnt signaling pathway. In the current model of this pathway, the amount of β‐cateninExpand
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Histone methylation by PRC2 is inhibited by active chromatin marks.
The Polycomb repressive complex 2 (PRC2) confers transcriptional repression through histone H3 lysine 27 trimethylation (H3K27me3). Here, we examined how PRC2 is modulated by histone modificationsExpand
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Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors
We describe a chemical proteomics approach to profile the interaction of small molecules with hundreds of endogenously expressed protein kinases and purine-binding proteins. This subproteome isExpand
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A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.
Signal transduction pathways are modular composites of functionally interdependent sets of proteins that act in a coordinated fashion to transform environmental information into a phenotypicExpand
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RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling
The Wnt/β-catenin signalling pathway plays essential roles in embryonic development and adult tissue homeostasis, and deregulation of this pathway has been linked to cancer. Axin is aExpand
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A physical and functional map of the human TNF-α/NF-κB signal transduction pathway
Signal transduction pathways are modular composites of functionally interdependent sets of proteins that act in a coordinated fashion to transform environmental information into a phenotypicExpand
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TRAF4 promotes TGF-β receptor signaling and drives breast cancer metastasis.
TGF-β signaling is a therapeutic target in advanced cancers. We identified tumor necrosis factor receptor-associated factor 4 (TRAF4) as a key component mediating pro-oncogenic TGF-β-induced SMAD andExpand
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