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Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia coli
Significance Only a tiny fraction (<2%) of the unique structures in the protein database correspond to membrane proteins, and only a few of these are of eukaryotic origin, representing potential drugExpand
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Native phasing of x-ray free-electron laser data for a G protein–coupled receptor
Anomalous signal from sulfur atoms present in most proteins was used for de novo phasing of XFEL data and solving a GPCR structure. Serial femtosecond crystallography (SFX) takes advantage ofExpand
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Structures of the intermediates of Kok’s photosynthetic water oxidation clock
Inspired by the period-four oscillation in flash-induced oxygen evolution of photosystem II discovered by Joliot in 1969, Kok performed additional experiments and proposed a five-state kinetic modelExpand
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Structural basis for ligand recognition at the human MT1 melatonin receptor
Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that maintains circadian rhythms1 by synchronization to environmental cues and is involved in diverse physiological processes2 such as theExpand
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Snapshot of an oxygen intermediate in the catalytic reaction of cytochrome c oxidase
Significance Crystal structures of intermediates in the reaction of oxygen (O2) with cytochrome c oxidase (CcO) have never been determined, limiting our understanding of the coupling between O2Expand
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Design and applications of a clamp for Green Fluorescent Protein with picomolar affinity
Green fluorescent protein (GFP) fusions are pervasively used to study structures and processes. Specific GFP-binders are thus of great utility for detection, immobilization or manipulation ofExpand
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Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor
Misoprostol is a life-saving drug in many developing countries for women at risk of post-partum hemorrhaging owing to its affordability, stability, ease of administration and clinical efficacy.Expand
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XFEL structures of the human MT2 melatonin receptor reveal basis of subtype selectivity
The human MT1 and MT2 melatonin receptors1,2 are G-protein-coupled receptors (GPCRs) that help to regulate circadian rhythm and sleep patterns3. Drug development efforts have targeted both receptorsExpand
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Structural Basis for Selectivity and Diversity in Angiotensin II Receptors
The angiotensin II receptors AT1R and AT2R serve as key components of the renin–angiotensin–aldosterone system. AT1R has a central role in the regulation of blood pressure, but the function of AT2RExpand
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XFEL structures of the human MT2melatonin receptor reveal the basis of subtype selectivity.
The human MT1 and MT2 melatonin receptors1,2 are G-protein-coupled receptors (GPCRs) that help to regulate circadian rhythm and sleep patterns3. Drug development efforts have targeted both receptorsExpand
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