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Stimulation of Human Endonuclease III by Y Box-binding Protein 1 (DNA-binding Protein B)
Human endonuclease III (hNth1) is a DNA glycosylase/apurinic/apyrimidinic lyase that initiates base excision repair of pyrimidines modified by reactive oxygen species, ionizing, and ultraviolet radiation and interaction with the damage-inducible transcription factor Y box-binding protein 1 (YB-1), also identified as DNA-bindingprotein B (DbpB). Expand
Genetic effects of oxidative DNA damages: comparative mutagenesis of the imidazole ring-opened formamidopyrimidines (Fapy lesions) and 8-oxo-purines in simian kidney cells
This is the first investigation using extrachromosomal probes containing a Fapy·dG or Fap·dA site-specifically incorporated, which showed unequivocally that in simian kidney cells Fapy–G→T substitutions occur at a higher frequency than 8-oxo-G →T and that Fapy ·dA is very weakly mutagenic, as is 8-Oxo-dA. Expand
Substrate Specificity of Human Endonuclease III (hNTH1)
It is demonstrated here that hNTH1 was inhibited by the product of its DNA N-glycosylase activity directed against Tg:G, the AP:G site, in contrast, hNth1 was not as inhibited byThe AP:A site arising from release of Tg from TG:A. Expand
Mechanistic Studies of the Bypass of a Bulky Single-base Lesion Catalyzed by a Y-family DNA Polymerase*
1-Nitropyrene, the most abundant nitro polycyclic aromatic hydrocarbon in diesel emissions, has been found to react with DNA to form predominantly N-(deoxyguanosin-8-yl)-1-aminopyrene (dGAP). ThisExpand
Mutagenicity of the 1-nitropyrene-DNA adduct N-(deoxyguanosin-8-yl)-1-aminopyrene in mammalian cells.
It is concluded that C8-AP-dG mutagenesis depends on the type of cell in which it is replicated, the neighboring DNA sequence, and the methylation status of the 5'-C, even though in bacteria CpG deletions predominate in this sequence. Expand
Specific and efficient binding of xeroderma pigmentosum complementation group A to double-strand/single-strand DNA junctions with 3'- and/or 5'-ssDNA branches.
It is proposed that, besides DNA damage recognition, XPA may also play a novel role in stabilizing, via its high affinity to ds-ssDNA junctions, the DNA strand opening surrounding the lesion for stable formation of preincision NER intermediates. Expand
Structure of (5'S)-8,5'-cyclo-2'-deoxyguanosine in DNA.
The structure of an oligodeoxynucleotide duplex containing a site-specific S-cdG lesion placed opposite dC in the complementary strand was obtained by molecular dynamics calculations restrained by distance and dihedral angle restraints obtained from NMR spectroscopy. Expand
Targeted Deletion of mNth1 Reveals a Novel DNA Repair Enzyme Activity
This previously undescribed, and hence novel, back-up enzyme activity may function to repair oxidized 5meCyt residues in DNA while also being sufficient to compensate for the loss of Nth1 in the mutant mice, thereby explaining the noninformative phenotype. Expand