• Publications
  • Influence
Measurements of rat and mouse gastrointestinal pH, fluid and lymphoid tissue, and implications for in‐vivo experiments
TLDR
Substantial amounts of lymphoid tissue analagous to small intestinal Peyer's patches were measured in the rat and mouse colon, showing the feasibility of colonic vaccination, a route which might prove to have different applications to the more commonly studied oral vaccines. Expand
The gastrointestinal microbiota as a site for the biotransformation of drugs.
TLDR
The objective of this review is the provision of a comprehensive overview of the gastrointestinal microbiota, their drug substrates and metabolic mechanisms, and approaches to studying this further are discussed. Expand
Gut instincts: explorations in intestinal physiology and drug delivery.
TLDR
A discussion on intestinal physiology is utilised to address those areas which require further research and understanding, and new technologies are highlighted. Expand
Fused-filament 3D printing (3DP) for fabrication of tablets.
TLDR
The study indicates that FF 3DP has the potential to offer a new solution for fabricating personalized-dose medicines or unit dosage forms with controlled-release profiles and the low cost of FDM printers means the paradigm of extemporaneous or point-of-use manufacture of personalized- dose tablets is both feasible and attainable. Expand
Effect of geometry on drug release from 3D printed tablets.
TLDR
This work has demonstrated the potential of 3DP to manufacture tablet shapes of different geometries, many of which would be challenging to manufacture by powder compaction. Expand
Review on materials & methods to produce controlled release coated urea fertilizer.
TLDR
The development of CRCU is a green technology that not only reduces nitrogen loss caused by volatilization and leaching, but also alters the kinetics of nitrogen release, which provides nutrients to plants at a pace that is more compatible with their metabolic needs. Expand
3D printing of modified-release aminosalicylate (4-ASA and 5-ASA) tablets.
TLDR
The potential role of FDM 3DP as an efficient and low-cost alternative method of manufacturing individually tailored oral drug dosage, and also for production of modified-release formulations, is demonstrated. Expand
Sequential recruitment of neutrophils into lung and bronchoalveolar lavage fluid in LPS-induced acute lung injury.
TLDR
Findings confirm LPS-induced migration of PMN into the lung, and for the first time, distinct transmigration steps into the different lung compartments are characterized in vivo. Expand
Stereolithographic (SLA) 3D printing of oral modified-release dosage forms.
TLDR
SLA 3DP technology allows the manufacture of drug loaded tablets with specific extended-release profiles and could become a manufacturing technology for the elaboration of oral dosage forms, for industrial production or even for personalised dose. Expand
ICAM-1 and LFA-1 play critical roles in LPS-induced neutrophil recruitment into the alveolar space.
TLDR
It is concluded that ICAM-1 and L FA-1 play critical roles in the recruitment of neutrophils into the alveolar space in aerosolized LPS-induced lung inflammation, and LFA-1 serves as a ligand of ICam-1 in the lung. Expand
...
1
2
3
4
5
...