• Publications
  • Influence
Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: a report from the American Society of Echocardiography and the European Association of
TLDR
The non-invasive evaluation of LVEF has gained importance, and notwithstanding the limitations of the techniques used for its calculation, has emerged as the most widely used strategy for monitoring the changes in cardiac function, both during and after the administration of potentially cardiotoxic cancer treatment. Expand
Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline.
TLDR
Recommendations for prevention and monitoring of cardiac dysfunction in survivors of adult-onset cancers were developed by an expert panel with multidisciplinary representation using a systematic review of meta-analyses, randomized clinical trials, observational studies, and clinical experience. Expand
Class IV Semaphorins Promote Angiogenesis by Stimulating Rho-Initiated Pathways through Plexin-B
TLDR
The role of plexin-B1 activation in angiogenesis is examined using a purified, secreted form of its ligand, Semaphorin 4D (Sema4D), which potently induced chemotaxis and tubulogenesis in endothelial cells and enhanced blood vessel formation in an in vivo mouse model. Expand
Direct Interaction of p21-Activated Kinase 4 with PDZ-RhoGEF, a G Protein-linked Rho Guanine Exchange Factor*
TLDR
Evidence is provided that PAK4 can negatively regulate the activation of Rho through a direct protein-protein interaction with G protein-linked Rho GEFs, thus providing a novel potential mechanism for cross-talk among Rho GTPases. Expand
Cardiovascular Disease and Breast Cancer: Where These Entities Intersect A Scientific Statement From the American Heart Association
TLDR
This document will provide a comprehensive overview of the prevalence of these diseases, shared risk factors, the cardiotoxic effects of therapy, and the prevention and treatment of CVD in breast cancer patients. Expand
The small GTPase Rac1 links the Kaposi sarcoma-associated herpesvirus vGPCR to cytokine secretion and paracrine neoplasia.
TLDR
Results identify Rac1 as a key mediator of vGPCR paracrine neoplasia, suggesting that this small G protein and its downstream effectors may represent suitable therapeutic targets for the treatment of KS. Expand
Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential
TLDR
These findings suggest the existence of a novel mechanism controlling the activity of PDZ-RhoGEF, LARG, and p115Rho GEFs, which involves homo- and hetero-oligomerization through their inhibitory C-terminal region. Expand
Cardiovascular Health of Patients With Cancer and Cancer Survivors: A Roadmap to the Next Level.
TLDR
Current aspects of interdisciplinary cardio-oncology clinical care delivery and education in the United States is examined and how these data provide a platform for future development of the field is outlined. Expand
G Protein-Coupled Receptor-Mediated Mitogen-Activated Protein Kinase Activation through Cooperation of Gαq and Gαi Signals
  • Andree Blaukat, A. Barac, M. Cross, Stefan Offermanns, Ivan Dikic
  • Medicine, Biology
  • Molecular and Cellular Biology
  • 15 September 2000
TLDR
It is concluded that dually coupled GPCRs require a cooperation of Gαi- and Gq/11-mediated pathways for efficient stimulation of the ERK cascade, and cooperative signaling by multiple G proteins thus might represent a novel concept implicated in the regulation of cellular responses by GPCR. Expand
Management of cardiac disease in cancer patients throughout oncological treatment: ESMO consensus recommendations.
TLDR
Common CV toxicities related to cancer therapy are defined, along with suggested strategies for prevention, detection and treatment, and guidance regarding prevention, screening, monitoring and treatment of CV toxicity is provided. Expand
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