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Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1
Alagille syndrome is an autosomal dominant disorder characterized by abnormal development of liver, heart, skeleton, eye, face and, less frequently, kidney. Analyses of many patients with cytogeneticExpand
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A ubiquitous thermoacidophilic archaeon from deep-sea hydrothermal vents
Deep-sea hydrothermal vents are important in global biogeochemical cycles, providing biological oases at the sea floor that are supported by the thermal and chemical flux from the Earth's interior.Expand
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Thermodesulfobacterium hydrogeniphilum sp. nov., a thermophilic, chemolithoautotrophic, sulfate-reducing bacterium isolated from a deep-sea hydrothermal vent at Guaymas Basin, and emendation of the
A thermophilic, non-spore-forming, marine, sulfate-reducing bacterium, strain SL6T, was isolated from deep-sea hydrothermal sulfides collected at Guaymas Basin. The gram-negative-staining cellsExpand
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The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1.
A cDNA clone encoding the human homolog of rat Jagged1 was isolated from normal human marrow. Analyses of human stromal cell lines indicate that this gene, designated hJagged1, is expressed by marrowExpand
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Key features of σS required for specific recognition by Crl, a transcription factor promoting assembly of RNA polymerase holoenzyme
Significance Bacteria can change the relative amounts of different sigma factors that associate with the RNA polymerase (RNAP) catalytic core enzyme, thereby altering the relative amounts of the RNAPExpand
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Microbial diversity of a sulphide spire located in the Edmond deep-sea hydrothermal vent field on the Central Indian Ridge
A culture-independent molecular phylogenetic survey was carried out for a bacterial and archaeal community of a mineralized crust coating a sulphide spire, which was collected from the Edmond ventExpand
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Biogeochemistry: Microbial essentials at hydrothermal vents
Hot, anoxic fluids emerging from deep-sea hydrothermal vents mix suddenly with cold oxygenated sea water, providing ideal microbial niches for organisms that need limited amounts of oxygen. We haveExpand
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ppGpp and DksA likely regulate the activity of the extracytoplasmic stress factor σE in Escherichia coli by both direct and indirect mechanisms
One of the major signalling pathways responsible for intercompartmental communication between the cell envelope and cytoplasm in Escherichia coli is mediated by the alternative sigma factor, σE. σEExpand
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Diversity of 16S rRNA gene, ITS region and aclB gene of the Aquificales
The Aquificales are prevalent members of the microbial communities inhabiting many marine and terrestrial hydrothermal systems. Numerous new strains were obtained from deep-sea and terrestrialExpand
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Structure of the RNA polymerase assembly factor Crl and identification of its interaction surface with sigma S.
Bacteria utilize multiple sigma factors that associate with core RNA polymerase (RNAP) to control transcription in response to changes in environmental conditions. In Escherichia coli and SalmonellaExpand
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