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Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.
TLDR
Structural features of the receptor that are critical to selectivity and efficacy can be used to design highly D3R-selective ligands with targeted efficacies and are generalizable to other GPCRs in which the SBP can be targeted by bitopic or allosteric ligands.
A Single Glycine in Extracellular Loop 1 Is the Critical Determinant for Pharmacological Specificity of Dopamine D2 and D3 Receptors
TLDR
It is demonstrated that the 4-phenylpiperazine moiety in this class of D3R-selective compounds binds to the conserved orthosteric binding site, whereas the extended aryl amide moiety is oriented toward a divergent secondary binding pocket (SBP).
Effects of buspirone and the dopamine D3 receptor compound PG619 on cocaine and methamphetamine self-administration in rhesus monkeys using a food-drug choice paradigm
TLDR
PG619 did not affect cocaine or MA choice, while buspirone increased low-dose cocaine choice and suggest that food-drug choice paradigms may have greater predictive validity than the use of other schedules of reinforcement.
High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice
TLDR
A series of D3R-selective 4-phenylpiperazines with improved metabolic stability and off-target binding at selected 5-HT receptor subtypes are reported, including compounds 16 and the classic D 3R antagonist SB277011A, which were effective in reducing self-administration of heroin in wild-type but not D2R knockout mice.
Influence of Cocaine History on the Behavioral Effects of Dopamine D3 Receptor-Selective Compounds in Monkeys
TLDR
An incongruence between in vitro and in vivo assays is suggested and a history of cocaine self-administration can affect in vivo efficacy of D3 receptor-preferring compounds PG 619 and CJB 090, which appear to be dependent on the behavioral assay.
Chiral Resolution and Serendipitous Fluorination Reaction for the Selective Dopamine D3 Receptor Antagonist BAK2-66.
The improved chiral synthesis of the selective dopamine D3 receptor (D3R) antagonist (R)-N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-hydroxybutyl)1H-indole-2-carboxamide (( R )-PG648) is described.
N-(3-fluoro-4-(4-(2-methoxy or 2,3-dichlorophenyl)piperazine-1-yl)butyl)arylcarboxamides as selective dopamine D3 receptor ligands: critical role of the carboxamide linker for D3 receptor selectivity.
TLDR
A pivotal role is supported for the D3R E2 loop and the carbonyl group in the 4-phenylpiperazine class of compounds and a point of separation between structure-activity relationships at D3 R and D2R is revealed.
Using click chemistry toward novel 1,2,3-triazole-linked dopamine D3 receptor ligands.
Design and synthesis of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) analogues as novel probes for the serotonin transporter S1 and S2 binding
TLDR
Structural modifications to the N, 4, 5, and 4' positions of (±)citalopram are reported, and eight analogues were identified with similar potencies to S-1 for decreasing the dissociation of [(3)H]S-1 from the S1 site via allosteric modulation at S2.
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