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Clinical responses to gene therapy in joints of two subjects with rheumatoid arthritis.
This paper provides the first evidence of a clinical response to gene therapy in human arthritis. Two subjects with rheumatoid arthritis received ex vivo, intraarticular delivery of humanExpand
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Genetic enhancement of fracture repair: healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene
This study evaluated the ability of gene transfer to enhance bone healing. Segmental defects were created surgically in the femora of New Zealand white rabbits. First generation adenoviruses wereExpand
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Effect of BMP-2 gene transfer on bone healing in sheep
Critical size defects of bone and delayed fracture healing due to metabolic disorders are still problems in orthopaedic surgery. Adenoviral vectors encoding bone morphogenetic protein-2 (Ad.BMP-2)Expand
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Interleukin-12 and interleukin-18 induce indoleamine 2,3-dioxygenase (IDO) activity in human osteosarcoma cell lines independently from interferon-gamma.
PURPOSE In this study we evaluated the ability of inducing activation of the enzyme indoleamine 2,3-dioxygenase (IDO) for the development of a new adjuvant therapy of osteosarcomas. The pathway thatExpand
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Potential role of direct adenoviral gene transfer in enhancing fracture repair.
Gene therapy has much to offer in the treatment of conditions in which it is necessary to increase the formation of bone. Nonunions, segmental defects, and aseptic loosening are examples ofExpand
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Immunotherapy by gene transfer with plasmids encoding IL-12/IL-18 is superior to IL-23/IL-18 gene transfer in a rat osteosarcoma model.
BACKGROUND Osteosarcomas are primary malignant tumors of bone or soft parts arising from bone-forming mesenchymal cells. Despite dramatic therapeutic advances, namely neo-adjuvant and adjuvantExpand
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A gene therapy approach to accelerating bone healing Evaluation of gene expression in a New Zealand white rabbit model
It has been demonstrated that BMPs, IGFs, and TGFβs improve the process of bone healing in vivo. We have suggested the use of gene therapy as a possible way to deliver growth factors to fractureExpand
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Experimentelle Validierung einer DXA- und MRT-basierten Knochendichtemessung durch Veraschung
: Different methods have been established for bone density measurements such as dual energy X-ray absorptiometry (DXA), quantitative computertomography (QCT), and scintigraphy (VQ-Scan). There areExpand
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Good short- to medium-term results after osteochondral autograft transplantation (OAT) in middle-aged patients with focal, non-traumatic osteochondral lesions of the knee.
BACKGROUND Osteochondral autograft transplantation (OAT) offers the opportunity to repair cartilaginous defects by restoring hyaline cartilage anatomy. Encouraging results have been reported inExpand
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AUTOLOGOUS CONDITIONED SERUM (ACS) COMPARED TO HYALURONAN AND SALINE-INJECTIONS FOR THE TREATMENT OF KNEE OSTEOARTHRITIS: (RCT-ISRCTN: 71311752)
Aims A new therapy, based on the intra-articular injection of autologous conditioned serum (ACS), is used in several European countries for osteoarthritis (OA) treatment. ACS is generated byExpand
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