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Activity and Stability Studies of Verbascoside, a Novel Antioxidant, in Dermo-Cosmetic and Pharmaceutical Topical Formulations
We here report the results of our investigations carried out on verbascoside, a phenylpropanoid glycoside known for its antioxidant, anti-inflammatory and photoprotective actions. Verbascoside wasExpand
In vitro and in vivo studies on UFP-112, a novel potent and long lasting agonist selective for the nociceptin/orphanin FQ receptor
It is demonstrated that UFP-112 behaves in vitro and in vivo as a highly potent and selective ligand able to produce full and long lasting activation of NOP receptors. Expand
Essential oil extraction, chemical analysis and anti-Candida activity of Foeniculum vulgare Miller – new approaches
The predominance and continued presence of o-cymene makes this fennel oil a rather unique chemotype and an evident correlation between the antifungal activity and phenological stage is demonstrated. Expand
Peptidyl vinyl ester derivatives: new class of selective inhibitors of proteasome trypsin-like activity.
These tripeptide-based compounds bearing a C-terminal vinyl ester are nontoxic, and do not affect cell proliferation, but are able to modulate the generation and presentation of immunogenic peptides presented by MHC class I molecules. Expand
Design, synthesis and biological activity of a novel Rutin analogue with improved lipid soluble properties.
The synthesis, antimicrobial, antiproliferative and pro-apoptotic effect on human leukemic K562 cells of compound R2, a new semi-synthetic derivative of Rutin as compared to Rutin itself, found to be more effective than parent Rutin. Expand
In vitro and in vivo pharmacological characterization of the nociceptin/orphanin FQ receptor ligand Ac-RYYRIK-ol.
In vivo in mice, Ac-RYYRIK-ol displayed a complex pharmacological profile which is likely due to the low efficacy agonist nature of this novel ligand of the NOP receptor, and the high potency, selectivity of action, and in vivo effectiveness make Ac-ryYRIk-ol a useful pharmacological tool for future studies in the field of N/OFQ and its Nop receptor. Expand
Arecoline tripeptide inhibitors of proteasome.
Derivatives 17-19 are the best compounds of the series, showing chymotryptic-like (beta5) inhibition (IC(50) congruent with 1 microM) and favorable pharmacokinetic properties. Expand
Monoolein aqueous dispersions as a delivery system for quercetin
The preparation, characterization and in vitro release of monoolein aqueous dispersions (MAD) encapsulating quercetin (QT) are described to conclude that MAD can be potentially proposed for the delivery of QT. Expand
Synthesis, Antioxidant and Antimicrobial Activity of a New Phloridzin Derivative for Dermo-Cosmetic Applications
Antifungal activity of phloridzin and its derivative F2 were determined; the results, however, were rather low; the highest value was 31,6% of inhibition reached by F2 on Microsporum canis at the highest dose. Expand
Vinyl ester-based cyclic peptide proteasome inhibitors.
The synthesis and biological properties of a new series of vinyl ester cyclopeptide analogues are reported, shown to inhibit the chymotrypsin-like activity of the proteasome at nanomolar concentration and their potency was found to depend on the size of the tetrapeptidic cyclic portion. Expand