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The purification of a gs antigen of the murine mammary tumor virus and its quantitation by radioimmunoassay.
Abstract A method using Concanavalin (ConA) affinity chromatography has been developed for the purification of the mouse mammary tumor virus (MuMTV) gs antigens (gp52) and (p27). The procedureExpand
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Multidrug Resistance Protein 4 (MRP4/ABCC4) Regulates cAMP Cellular Levels and Controls Human Leukemia Cell Proliferation and Differentiation*
Increased intracellular cAMP concentration plays a well established role in leukemic cell maturation. We previously reported that U937 cells stimulated by H2 receptor agonists, despite a robustExpand
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Carcinoma‐associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF‐2/FGFR‐2 axis
The mechanisms by which mammary carcinomas acquire hormone independence are still unknown. To study the role of cancer‐associated fibroblasts (CAF) in the acquisition of hormone‐independence we usedExpand
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Mitoxantrone affects topoisomerase activities in human breast cancer cells.
The effects of mitoxantrone, an antineoplastic DNA intercalator, on topoisomerase I and II were studied in two human breast cancer cell lines. A large increase of topoisomerase I activity was foundExpand
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Human breast cell lines exhibit functional α2-adrenoceptors
Adrenergic compounds (epinephrine and norepinephrine) are the most important hormones released during stress. Several different receptors are associated with their action in different tissues.Expand
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Three novel hormone‐responsive cell lines derived from primary human breast carcinomas: Functional characterization
Human breast cancer primary cultures are useful tools for the study of several aspects of cancer biology, including the effects of chemotherapy and acute gene expression in response to differentExpand
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Incidence of estrogen, progesterone and prolactin receptors in human breast cancer.
Analysis of estrogen and progesterone cytosolic receptors (ER, PR) has been studied in human breast carcinoma. ER were assayed by sucrose density gradients and dextran coated-charcoal method. In aExpand
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Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective
Previous studies indicated the need of at least one phenolic hydroxyl group in the coumarin core for induction of cytotoxicity in different cell lines. Herein, we present an exhaustiveExpand
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Histamine H2 Receptor Trafficking: Role of Arrestin, Dynamin, and Clathrin in Histamine H2 Receptor Internalization
Agonist-induced internalization of G protein-coupled receptors (GPCRs) has been implicated in receptor desensitization, resensitization, and down-regulation. In the present study, we sought toExpand
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The time-course of cyclic AMP signaling is critical for leukemia U-937 cell differentiation.
The regulation of the cAMP signaling is intimately involved in several cellular processes, including cell differentiation. Here, we provide strong evidence supporting that the time-course of cAMPExpand
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