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Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.
- R. Saxena, C. Elbers, +152 authors B. Keating
- Biology, Medicine
- American journal of human genetics
- 9 March 2012
To identify genetic factors contributing to type 2 diabetes (T2D), we performed large-scale meta-analyses by using a custom ∼50,000 SNP genotyping array (the ITMAT-Broad-CARe array) with ∼2000… Expand
Prevalence of diabetes, metabolic syndrome, and cardiovascular risk factors in US Asian Indians: results from a national study.
- Ranjita Misra, Thakor G. Patel, +8 authors A. Balasubramanyam
- Journal of diabetes and its complications
- 1 May 2010
BACKGROUND Although studies of immigrant Asian Indians in other countries show high rates of diabetes (DM), metabolic syndrome (MetS), and cardiovascular disease (CVD), no randomized,… Expand
RhoA Signaling via Serum Response Factor Plays an Obligatory Role in Myogenic Differentiation*
- L. Wei, W. Zhou, +4 authors R. Schwartz
- Biology, Medicine
- The Journal of Biological Chemistry
- 13 November 1998
Serum response factor (SRF) plays a central role during myogenesis, being required for the expression of striated α-actin genes. As shown here, the small GTPase RhoA-dependent activation of SRF… Expand
Ketosis-prone diabetes: dissection of a heterogeneous syndrome using an immunogenetic and beta-cell functional classification, prospective analysis, and clinical outcomes.
- M. Maldonado, C. S. Hampe, +8 authors A. Balasubramanyam
- The Journal of clinical endocrinology and…
- 1 November 2003
Ketosis-prone diabetes is heterogeneous. Its causes could include novel beta-cell functional defects. To characterize such defects, 103 patients with diabetic ketoacidosis were evaluated for… Expand
Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes
Fructose consumption predicts increased hepatic fibrosis in those with nonalcoholic fatty liver disease (NAFLD). Because of its ability to lower hepatic adenosine triphosphate (ATP) levels, habitual… Expand
Syndromes of ketosis-prone diabetes mellitus.
Ketosis-prone diabetes (KPD) is a widespread, emerging, heterogeneous syndrome characterized by patients who present with diabetic ketoacidosis or unprovoked ketosis but do not necessarily have the… Expand
The Role of the Immune System in Obesity and Insulin Resistance
The innate immune system provides organisms with rapid and well-coordinated protection from foreign pathogens. However, under certain conditions of metabolic dysfunction, components of the innate… Expand
Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation.
- R. Sekhar, Sanjeet G. Patel, +4 authors F. Jahoor
- Chemistry, Medicine
- The American journal of clinical nutrition
- 1 September 2011
BACKGROUND Aging is associated with oxidative stress, but underlying mechanisms remain poorly understood. OBJECTIVE We tested whether glutathione deficiency occurs because of diminished synthesis… Expand
New profiles of diabetic ketoacidosis: type 1 vs type 2 diabetes and the effect of ethnicity.
- A. Balasubramanyam, J. W. Zern, D. Hyman, V. Pavlik
- Archives of internal medicine
- 25 October 1999
BACKGROUND Diabetic ketoacidosis (DKA) has been reported to occur in type 2 diabetes, but the frequency and distinguishing features of this syndrome remain to be defined. We determined the "diabetic… Expand
Dysregulation of glucose metabolism in HIV patients: epidemiology, mechanisms, and management
HIV-infected patients on highly active antiretroviral therapy (HAART) have increased prevalence of a number of chronic metabolic disorders of multifactorial but unclear etiology. These include… Expand