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IL28B and the control of hepatitis C virus infection.
Treatment-induced control and spontaneous clearance of hepatitis C virus (HCV) infection are affected by various host factors. Polymorphisms in the region of the gene IL28B are associated with HCVExpand
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Presence of Human Hepegivirus-1 in a Cohort of People Who Inject Drugs
Humans are teeming with microbes that comprise our microbiome and contribute to health and disease. A typical human with 1012 nucleated cells is estimated to have 1015 virions and 1013 bacteria (1,Expand
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Human immunodeficiency virus-related microbial translocation and progression of hepatitis C.
BACKGROUND & AIMS Human immunodeficiency virus (HIV)-1 infection has been associated with enhanced microbial translocation, and microbial translocation is a mechanism through which alcohol and someExpand
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CD161+ MAIT Cells Are Severely Reduced in Peripheral Blood and Lymph Nodes of HIV-Infected Individuals Independently of Disease Progression
Mucosal-associated invariant T (MAIT) cells are characterized by the combined expression of the semi-invariant T cell receptor (TCR) Vα7.2, the lectin receptor CD161, as well as IL-18R, and play anExpand
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Inferring Viral Dynamics in Chronically HCV Infected Patients from the Spatial Distribution of Infected Hepatocytes
Chronic liver infection by hepatitis C virus (HCV) is a major public health concern. Despite partly successful treatment options, several aspects of intrahepatic HCV infection dynamics are stillExpand
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The transhepatic endotoxin gradient is present despite liver cirrhosis and is attenuated after transjugular portosystemic shunt (TIPS).
BackgroundTranslocation of gut-derived bacterial products such as endotoxin is a major problem in liver cirrhosis.MethodsTo assess the hepatic clearance of bacterial products in individuals withExpand
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Sex-Related Differences in Inflammatory and Immune Activation Markers Before and After Combined Antiretroviral Therapy Initiation
Background:Women progress to death at the same rate as men despite lower plasma HIV RNA (viral load). We investigated sex-specific differences in immune activation and inflammation as a potentialExpand
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Kupffer cells are depleted with HIV immunodeficiency and partially recovered with antiretroviral immune reconstitution
Objectives:HIV-related enhancement of gut microbial translocation is associated with progression of hepatic fibrosis. Although hepatic macrophages (Kupffer cells) clear most microbial translocationExpand
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Detection and treatment of Strongyloides hyperinfection syndrome following lung transplantation
Abstract: Strongyloides hyperinfection syndrome has not been reported in lung transplant recipients. We describe the case of a 61‐year‐old Peruvian man, who received bilateral lung transplants forExpand
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Liver stiffness is associated with monocyte activation in HIV-infected Ugandans without viral hepatitis.
A high prevalence of liver stiffness, as determined by elevated transient elastography liver stiffness measurement, was previously found in a cohort of HIV-infected Ugandans in the absence of chronicExpand
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