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IL28B and the control of hepatitis C virus infection.
Treatment-induced control and spontaneous clearance of hepatitis C virus (HCV) infection are affected by various host factors. Polymorphisms in the region of the gene IL28B are associated with HCV… Expand
Presence of Human Hepegivirus-1 in a Cohort of People Who Inject Drugs
- A. Kandathil, F. Breitwieser, +6 authors A. Balagopal
- Annals of Internal Medicine
- 16 January 2018
Humans are teeming with microbes that comprise our microbiome and contribute to health and disease. A typical human with 1012 nucleated cells is estimated to have 1015 virions and 1013 bacteria (1,… Expand
Human immunodeficiency virus-related microbial translocation and progression of hepatitis C.
BACKGROUND & AIMS Human immunodeficiency virus (HIV)-1 infection has been associated with enhanced microbial translocation, and microbial translocation is a mechanism through which alcohol and some… Expand
CD161+ MAIT Cells Are Severely Reduced in Peripheral Blood and Lymph Nodes of HIV-Infected Individuals Independently of Disease Progression
Mucosal-associated invariant T (MAIT) cells are characterized by the combined expression of the semi-invariant T cell receptor (TCR) Vα7.2, the lectin receptor CD161, as well as IL-18R, and play an… Expand
Inferring Viral Dynamics in Chronically HCV Infected Patients from the Spatial Distribution of Infected Hepatocytes
- Frederik Graw, A. Balagopal, +4 authors A. Perelson
- Biology, Medicine
- PLoS Comput. Biol.
- 1 November 2014
We present methods to analyze the spatial distribution of infected hepatocytes obtained by single cell laser capture microdissection from liver biopsy samples of patients chronically infected with HCV. Expand
The transhepatic endotoxin gradient is present despite liver cirrhosis and is attenuated after transjugular portosystemic shunt (TIPS).
BackgroundTranslocation of gut-derived bacterial products such as endotoxin is a major problem in liver cirrhosis.MethodsTo assess the hepatic clearance of bacterial products in individuals with… Expand
Sex-Related Differences in Inflammatory and Immune Activation Markers Before and After Combined Antiretroviral Therapy Initiation
- J. Mathad, N. Gupte, +18 authors A. Gupta
- Journal of acquired immune deficiency syndromes
- 1 October 2016
Background:Women progress to death at the same rate as men despite lower plasma HIV RNA (viral load). We investigated sex-specific differences in immune activation and inflammation as a potential… Expand
Kupffer cells are depleted with HIV immunodeficiency and partially recovered with antiretroviral immune reconstitution
Objectives:HIV-related enhancement of gut microbial translocation is associated with progression of hepatic fibrosis. Although hepatic macrophages (Kupffer cells) clear most microbial translocation… Expand
Detection and treatment of Strongyloides hyperinfection syndrome following lung transplantation
- A. Balagopal, L. Mills, A. Shah, A. Subramanian
- Transplant infectious disease : an official…
- 1 April 2009
Abstract: Strongyloides hyperinfection syndrome has not been reported in lung transplant recipients. We describe the case of a 61‐year‐old Peruvian man, who received bilateral lung transplants for… Expand
Liver stiffness is associated with monocyte activation in HIV-infected Ugandans without viral hepatitis.
- A. Redd, Sarah K. Wendel, +11 authors L. Stabinski
- AIDS research and human retroviruses
- 13 June 2013
A high prevalence of liver stiffness, as determined by elevated transient elastography liver stiffness measurement, was previously found in a cohort of HIV-infected Ugandans in the absence of chronic… Expand