Autism screening questionnaire: Diagnostic validity
- S. Berument, M. Rutter, C. Lord, A. Pickles, A. Bailey
- Medicine, PsychologyBritish Journal of Psychiatry
- 1 November 1999
The ASQ has good discriminative validity with respect to the separation of PDD from non-PDD diagnoses at all IQ levels, with a cut-off of 15 proving most effective.
Functional impact of global rare copy number variation in autism spectrum disorders
- D. Pinto, A. Pagnamenta, C. Betancur
- BiologyNature
- 15 July 2010
The genome-wide characteristics of rare (<1% frequency) copy number variation in ASD are analysed using dense genotyping arrays to reveal many new genetic and functional targets in ASD that may lead to final connected pathways.
Autism as a strongly genetic disorder: evidence from a British twin study
- A. Bailey, A. Le Couteur, M. Rutter
- Medicine, PsychologyPsychological Medicine
- 1 January 1995
The findings indicate that autism is under a high degree of genetic control and suggest the involvement of multiple genetic loci.
A case-control family history study of autism.
- P. Bolton, H. Macdonald, M. Rutter
- Psychology, MedicineJournal of Child Psychology and Psychiatry and…
- 1 July 1994
The findings suggest that the autism phenotype extends beyond autism as traditionally diagnosed; that aetiology involves several genes; that autism is genetically heterogeneous; and that obstetric abnormalities in autistic subjects may derive from abnormality in the foetus.
A clinicopathological study of autism.
- A. Bailey, P. Luthert, P. Lantos
- Medicine, PsychologyBrain : a journal of neurology
- 1 May 1998
A neuropathological study of autism was established and brain tissue examined from six mentally handicapped subjects with autism, finding the likely involvement of the cerebral cortex in autism.
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.
Mapping autism risk loci using genetic linkage and chromosomal rearrangements
- P. Szatmari, A. Paterson, K. J. Meyer
- BiologyNature Genetics
- 1 March 2007
Linkage and copy number variation analyses implicate chromosome 11p12–p13 and neurexins, respectively, among other candidate loci, highlighting glutamate-related genes as promising candidates for contributing to ASDs.
Convergence of Genes and Cellular Pathways Dysregulated in Autism Spectrum Disorders
- D. Pinto, E. Delaby, S. Scherer
- Biology, PsychologyAmerican Journal of Human Genetics
- 25 March 2014
Are there theory of mind regions in the brain? A review of the neuroimaging literature
- Sarah J. Carrington, A. Bailey
- Psychology, BiologyHuman Brain Mapping
- 1 August 2009
The functional imaging findings suggest that there are several “core” regions in the network—including parts of the prefrontal cortex and superior temporal sulcus—while several more “peripheral’ regions may contribute to ToM reasoning in a manner contingent on relatively minor aspects of the ToM task.
Analysis of shared heritability in common disorders of the brain
- V. Anttila, B. Bulik-Sullivan, B. Crespo-Facorro
- Psychology, MedicineScience
- 16 April 2016
It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures.
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