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Cluster headache: A prospective clinical study with diagnostic implications
Patients with cluster headache offer a population of primary headache patients with devastating acute attacks of pain and the syndrome is stereotyped with effective evidence-based treatments that are prescribed in only half of patients having cluster headache. Expand
Functional magnetic resonance imaging in spontaneous attacks of SUNCT: Short‐lasting neuralgiform headache with conjunctival injection and tearing
A 71‐year‐old woman presented with a short history of episodes of severe left‐sided orbital and temporal pain in paroxysms lasting 60 to 90 seconds, and accompanied by ipsilateral lacrimation of theExpand
Brainstem activation specific to migraine headache
The data show the potential for objective distinction between primary headache syndromes with functional imaging, in disorders hitherto distinguished on clinical grounds, and provide evidence that migraine involves the brainstem. Expand
Hypothalamic activation in cluster headache attacks
These findings establish central nervous system dysfunction in the region of the hypothalamus as the primum movens in the pathophysiology of cluster headache and suggest that this type of headache should be regarded as a neurovascular headache. Expand
PET and MRA findings in cluster headache and MRA in experimental pain
Dilatation of cranial vessels is not specific to any particular headache syndrome but generic to cranial neurovascular activation, probably mediated by the trigeminoparasympathetic reflex. Expand
Diagnostic delays and mis‐management in cluster headache
Objectives – Cluster headache is a stereotyped form of primary headache that while common in terms of neurologic illnesses is much less common as a cause of disabling headache than migraine.
Intranasal sumatriptan in cluster headache
Sumatriptan nasal spray is effective and well tolerated in the acute treatment of cluster headache attacks of at least 45 minutes’ duration and was also superior to placebo considering initial response, meaningful relief, and relief of associated symptoms. Expand
No change in the structure of the brain in migraine: a voxel‐based morphometric study
This study did not show any global or regional macroscopic structural difference between patients with migraine and controls, with migraine sufferers taken as homogenous groups, and if structural changes are to be found, other methods of phenotyping migraine may be required. Expand
Oral zolmitriptan is effective in the acute treatment of cluster headache
Oral zolmitriptan is efficacious in episodic cluster headache and was significantly superior to placebo for three of the four secondary endpoints, and well tolerated in patients with chronic cluster headache. Expand
Does Chronic Daily Headache Arise De Novo in Association With Regular Use of Analgesics?
A causal relationship has been suggested consequent to the observation of improvement or resolution of headache following analgesic withdrawal in patients attending headache clinics, but this observation has not been validated by controlled trials. Expand