• Publications
  • Influence
Williams trait. Human kininogen deficiency with diminished levels of plasminogen proactivator and prekallikrein associated with abnormalities of the Hageman factor-dependent pathways.
TLDR
Kininogen is a critical factor required for the functioning of Hageman factor-dependent coagulation and fibrinolysis and for the activation of prekallikrein. Expand
Virus inactivation in hemoglobin solutions by heat.
TLDR
It is found that the structure and function of deoxyhemoglobin are well preserved during incubation at 60 degrees C for 10 hours at a pH of 7.5. Expand
Activation of bovine factor VII by hageman factor fragments.
TLDR
It was found that Hageman factor fragments promoted rapid proteolysis of one-chain factor VII to a more active two-chain form, indicating that initiation of coagulation by the intrinsic pathway also primes the extrinsic pathway. Expand
Subcellular Localization and Purification of Blood
A protease inhibitor has been purified from platelets by ammonium sulfate fractionation, QAE Sephadex chromatography, Sephadex G-200 gel filtration, and affinity chromatography on concanavalinExpand
Activation of bovine factor VII by hageman factor fragments
TLDR
It was found that Hageman factor fragments promoted rapid proteolysis of one-chain factor VII to a more active two-chain form, indicating that initiation of coagulation by the intrinsic pathway also primes the extrinsic pathway. Expand
Isolation of high molecular weight activators of human plasma prekallikrein.
Abstract Two previously undescribed activators of prekallikrein have been purified from human plasma by alcohol fractionation, ion exchange chromatography, gel filtration, and polyacrylamide gelExpand
Potentiation of the function of Hageman factor fragments by high molecular weight kininogen.
TLDR
The results suggest that one of the functions of HMW kininogen is to augment the catalytic action of HFf, and that the hydrolysis of acetylglycyl-lysine methyl ester by HFf was increased by HMW Kininogen. Expand
Origin of the high molecular weight activator of prekallikrein.
TLDR
The results suggest that factor XII exhibits differential susceptibility to plasma proteolytic enzymes with both quantitative and qualitative changes in the prekallikrein activators formed, which might exert positive feedback control by converting factor XII to low molecular weight prekalikre in activators. Expand
Immunochemical studies of plasma kallikrein.
TLDR
The levels of prekallikrein antigen in plasma samples from patients with severe liver disease remains 40% of normal, while the functional kall Kikrein activity was about 8%. Expand
...
1
2
3
...