• Publications
  • Influence
Mass transfer and metabolic reactions in hepatocyte spheroids cultured in rotating wall gas-permeable membrane system.
Isolated hepatocytes in spheroid configuration exhibit a high degree of cell-cell contacts, which are important in the maintenance of viability and liver specific functions. In the absence of aExpand
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Repair of Chronic Osteochondral Defects Using Predifferentiated Mesenchymal Stem Cells in an Ovine Model
Background: The use of mesenchymal stem cells (MSCs) to treat osteochondral defects caused by sports injuries or disease is of particular interest. However, there is a lack of studies in large-animalExpand
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Both epithelial cells and mesenchymal stem cell-derived chondrocytes contribute to the survival of tissue-engineered airway transplants in pigs.
OBJECTIVE We sought to determine the relative contributions of epithelial cells and mesenchymal stem cell-derived chondrocytes to the survival of tissue-engineered airway transplants in pigs. Expand
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Moving towards in situ tracheal regeneration: the bionic tissue engineered transplantation approach
•  Introduction •  Rationales for tracheal transplantation •  Historical background •  Regenerative approach to tracheal replacement •  Human tissue engineering tracheal replacement ‐  DetergentExpand
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Impact of oxygen environment on mesenchymal stem cell expansion and chondrogenic differentiation
Introduction:  In vitro expansion and differentiation of mesenchymal stem cells (MSC) rely on specific environmental conditions, and investigations have demonstrated that one crucial factor is oxygenExpand
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Determination of pore size distribution at the cell-hydrogel interface
BackgroundAnalyses of the pore size distribution in 3D matrices such as the cell-hydrogel interface are very useful when studying changes and modifications produced as a result of cellular growth andExpand
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  • Open Access
Low Oxygen Expansion Improves Subsequent Chondrogenesis of Ovine Bone-Marrow-Derived Mesenchymal Stem Cells in Collagen Type I Hydrogel
Background/Objective: A crucial factor when investigating cartilage tissue engineering using mesenchymal stem cells (MSCs) is their application in large-animal models and preclinical trials. However,Expand
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Leukemia inhibitory factor modulates cardiogenesis in embryoid bodies in opposite fashions.
Cardiogenesis is a multistep process regulated by a hierarchy of factors defining each developmental stage of the heart. One of these factors, leukemia inhibitory factor (LIF), a member of theExpand
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  • Open Access
Identification of human cells in brain xenografts and in neural co-cultures of rat by in situ hybridisation with Alu probe
Transplantation of human cells into animal models of neurodegenerative disorders is an important scientific application to analyse the survival and developmental capacity of grafted human cells underExpand
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Hepatotoxicity and hepatic metabolism of available drugs: current problems and possible solutions in preclinical stages
Importance of the filed: According to a 2006 survey report of pharmaceutical companies, hepatotoxicity was ranked first in terms of adverse events and it remains the most common reason forExpand
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