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Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity
TLDR
Two different Stardust proteins are introduced here: one MAGUK protein, characterized by a PDZ domain, an SH3 domain and a guanylate kinase domain; and a second isoform comprising only the guanylation domain, which represents versatile candidates as structural and possibly regulatory constituents of the SAC, a crucial element in the control of epithelial cell polarity.
A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism
TLDR
SylA defines a new class of proteasome inhibitors that includes glidobactin A (GlbA), a structurally related compound from an unknown species of the order Burkholderiales, for which it is shown that SylA irreversibly inhibits all three catalytic activities of eukaryotic proteasomes, thus adding prote asome inhibition to the repertoire of modes of action of virulence factors.
Dissection of cis-regulatory elements of the Drosophila gene Serrate
TLDR
To understand the regulatory network required to control the spatially and temporally dynamic expression of Serrate, its cis-regulatory elements are analysed by fusing various genomic fragments upstream of the reporter gene lacZ.
A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma
TLDR
DFMO doses of 500-1500mg/m2/day are safe and well tolerated in children with relapsed NB and suggest that this patient subset may display dependence on polyamines and be uniquely susceptible to therapies targeting this pathway.
The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification
TLDR
Elevated ODC and low OAZ2 mRNA expression levels correlate with several unfavorable genetic and clinical features in NB, offering new insights into PA pathways and PA metabolism‐targeting therapy in NB.
The use of P-element transposons to generate transgenic flies.
TLDR
The development of a technique to stably integrate exogenous DNA into the germline of Drosophila melanogaster marked a milestone in the ability to study gene function in the fly and served as a general guideline for the transformation of other insect species including those with medical and agricultural importance.
Cell type-specific recruitment of Drosophila Lin-7 to distinct MAGUK-based protein complexes defines novel roles for Sdt and Dlg-S97
TLDR
Results imply that the recruitment of D Lin-7 to MAGUK-based protein complexes is defined by cell-type specific mechanisms and that DLin-7 acts downstream of Sdt in epithelia and downstream of Dlg at synapses.
Stay‐green genotypes of Phaseolus vulgaris L.: chloroplast proteins and chlorophyll catabolites during foliar senescence
TLDR
During senescence, normal leaf tissue accumulated an array of fluorescent (FCC) and non-fluorescent (NCC) compounds with chromatographic and spectrophotometric properties similar to those of chlorophyll catabolites previously identified in other species.
Withaferin A Inhibits STAT3 and Induces Tumor Cell Death in Neuroblastoma and Multiple Myeloma
TLDR
This study found that WFA effectively induces dose-dependent cell death in high-risk and drug-resistant NB as well as multiple myeloma (MM) tumor cells, prevented interleukin-6–mediated and persistently activated STAT3 phosphorylation at Y705, and blocked the transcriptional activity of STAT3.
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