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Structural and functional characterization of two alpha-synuclein strains
α-Synuclein aggregation is implicated in a variety of diseases including Parkinson's disease, dementia with Lewy bodies, pure autonomic failure and multiple system atrophy. The association of proteinExpand
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NMR Structure and Ion Channel Activity of the p7 Protein from Hepatitis C Virus*
The small membrane protein p7 of hepatitis C virus forms oligomers and exhibits ion channel activity essential for virus infectivity. These viroporin features render p7 an attractive target forExpand
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Atomic-resolution three-dimensional structure of HET-s(218-289) amyloid fibrils by solid-state NMR spectroscopy.
We present a strategy to solve the high-resolution structure of amyloid fibrils by solid-state NMR and use it to determine the atomic-resolution structure of the prion domain of the fungal prionExpand
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Atomic-Resolution Three-Dimensional Structure of Amyloid β Fibrils Bearing the Osaka Mutation**
Despite its central importance for understanding the molecular basis of Alzheimer's disease (AD), high-resolution structural information on amyloid β-peptide (Aβ) fibrils, which are intimately linkedExpand
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Proton assisted recoupling and protein structure determination.
We introduce a homonuclear version of third spin assisted recoupling, a second-order mechanism that can be used for polarization transfer between (13)C or (15)N spins in magic angle spinning (MAS)Expand
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De novo 3D structure determination from sub-milligram protein samples by solid-state 100 kHz MAS NMR spectroscopy.
Solid-state NMR spectroscopy is an emerging tool for structural studies of crystalline, membrane-associated, sedimented, and fibrillar proteins. A major limitation for many studies is still the largeExpand
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The usefulness of preoperative laboratory screening.
We assessed the usefulness of routine laboratory screening of preoperative patients. Computer-readable laboratory, demographic, and discharge diagnostic data were assembled for 2,000 patientsExpand
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Characterization of different water pools in solid-state NMR protein samples
We observed and characterized two distinct signals originating from different pools of water protons in solid-state NMR protein samples, namely from crystal water which exchanges polarization withExpand
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The amyloid-Congo red interface at atomic resolution.
Amyloids are b-sheet-rich proteinaceous aggregates that are a pathological hallmark of a number of human diseases. They can replicate by seeded nucleation and propagate as prions, and may even exertExpand
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Protocols for the Sequential Solid‐State NMR Spectroscopic Assignment of a Uniformly Labeled 25 kDa Protein: HET‐s(1‐227)
The sequence‐specific resonance assignment of a protein forms the basis for studies of molecular structure and dynamics, as well as to functional assay studies by NMR spectroscopy. Here we present aExpand
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