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Superoxide radicals as precursors of mitochondrial hydrogen peroxide
Vitamin E: non-antioxidant roles.
Vitamin E reduces the uptake of oxidized LDL by inhibiting CD36 scavenger receptor expression in cultured aortic smooth muscle cells.
It is shown here that the CD36 scavenger receptor (a specific receptor for oxLDL) is expressed in cultured human aortic smooth muscle cells (SMCs), and the beneficial effect of alpha-tocopherol against atherosclerosis can be explained, at least in part, by its effect of lowering the uptake of oxidized lipoproteins, with consequent reduction of foam cell formation.
The protein kinase C family.
- A. Azzi, D. Boscoboinik, C. Hensey
- Biology, Computer ScienceEuropean journal of biochemistry
- 1 September 1992
A better understanding of the exact cellular function of the different protein kinase C isoenzymes requires the identification and characterization of their physiological substrates.
Vitamin E: Emerging aspects and new directions
d-alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant…
- A. Tasinato, D. Boscoboinik, G. Bartoli, P. Maroni, A. Azzi
- BiologyProceedings of the National Academy of Sciences…
- 19 December 1995
It is concluded that, in vascular smooth muscle cells, d-alpha-tocopherol acts specifically through a nonantioxidant mechanism and exerts a negative control on a signal transduction pathway regulating cell proliferation.
Modulation of activator protein-1 (AP-1) transcription factor and protein kinase C by hydrogen peroxide and D-alpha-tocopherol in vascular smooth muscle cells.
- B. Stäuble, D. Boscoboinik, A. Tasinato, A. Azzi
- Biology, ChemistryEuropean journal of biochemistry
- 1 December 1994
The data show that hydrogen peroxide and D-alpha-tocopherol affect more than one element in the cell signal-transduction cascade, suggesting a non-antioxidant mechanism as the basis of its action.
Vitamin E: protective role of a Janus molecule
The new biochemical face of vitamin E was first described in 1991, with an inhibitory effect on cell proliferation and protein kinase C activity, and its nonantioxidant role is well established, as confirmed by authoritative studies of signal transduction and gene regulation.
Molecular mechanism of alpha-tocopherol action.
- A. Azzi
- BiologyFree radical biology & medicine
In vivo studies have shown that alpha-tocopherol is not able to protect against oxidant-induced damage or prevent disease allegedly caused by oxidative damage, and appears to act as a ligand of not yet identified specific proteins capable of regulating signal transduction and gene expression.