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Identification of a novel rickettsial infection in a patient diagnosed with murine typhus
- M. Schriefer, J. Sacci, J. Dumler, M. Bullen, A. Azad
- Medicine, BiologyJournal of Clinical Microbiology
- 1 April 1994
One of five tested patient blood samples was shown to be infected with ELB while R. typhi infections were confirmed in the remaining samples, which underscores the utility of PCR-facilitated diagnosis and discrimination of these closely related rickettsial infections.
Epidemiology of murine typhus.
- A. Azad
- BiologyAnnual Review of Entomology
Flea-borne rickettsioses: ecologic considerations.
- A. Azad, S. Radulovic, J. Higgins, B. Noden, J. Troyer
- Biology, MedicineEmerging Infectious Diseases
- 6 March 1997
In addition to the vector-host components of the murine typhus cycle, a second typhuslike rickettsia, R. felis, is uncovered from the blood of a hospitalized febrile patient and from opossums and their fleas.
A Rickettsia Genome Overrun by Mobile Genetic Elements Provides Insight into the Acquisition of Genes Characteristic of an Obligate Intracellular Lifestyle
Evidence is presented that conserved rickettsial genes associated with an intracellular lifestyle were acquired via MGEs, especially the RAGE, through a continuum of genomic invasions, making REIS one of the most plastic and repetitive bacterial genomes sequenced to date.
Rickettsial Infection in Dermacentor variabilis (Acari: Ixodidae) Inhibits Transovarial Transmission of a Second Rickettsia
- K. Macaluso, D. Sonenshine, S. Ceraul, A. Azad
- Medicine, BiologyJournal of medical entomology
- 1 November 2002
The resistance of the ovaries to co-infection and apparent host-specific nature of infection suggests that rickettsial infection of tick ovaries may alter the molecular expression of the oocytes so as to preclude secondary infection with other ricksettsiae.
Plasmids and Rickettsial Evolution: Insight from Rickettsia felis
A new rickettsial classification scheme is proposed with the addition of a fourth lineage, transitional group (TRG) ricksettsiae, that is unique from TG and SFG ricktsiae and harbors genes from possible exchanges with AG ricketsiae via conjugation.
Rickettsia Phylogenomics: Unwinding the Intricacies of Obligate Intracellular Life
A core of 752 rickettsial OGs was identified, depicting the essential Rickettsia genes, and non-representative OGs, as well as OGs comprised of several gene families typically involved in microbial pathogenicity and/or the acquisition of virulence factors, fall predominantly within C2OG distributions.
Rickettsial pathogens and their arthropod vectors.
Examination of the common features of the host-pathogen relationship and of the arthropod vectors of the typhus and spotted fever group rickettsiae finds efficient pathogen replication, long-term maintenance of infection, and transstadial and transovarial transmission.
Infection of colonized cat fleas, Ctenocephalides felis (Bouché), with a rickettsia-like microorganism.
- J. Adams, E. Schmidtmann, A. Azad
- Biology, MedicineAmerican Journal of Tropical Medicine and Hygiene
- 1 October 1990
We report the ultrastructure of a rickettsia-like microorganism in a colonized population of the cat flea Ctenocephalides felis (Bouché). The microorganism occurs principally in the cytoplasm of…
Genetic characterization and transovarial transmission of a typhus-like rickettsia found in cat fleas.
- A. Azad, J. Sacci, W. Nelson, G. Dasch, E. Schmidtmann, M. Carl
- Biology, MedicineProceedings of the National Academy of Sciences…
The DNA sequence of a portion of the 17-kDa PCR product of the rickettsia-like agent differed significantly from all known ricksettsial sequences and resembled the 17 -kDa sequences of typhus more than spotted fever group rickettiae.