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Effects of lithium on inflammation.
Lithium is an effective medication for the treatment of bipolar affective disorder. Accumulating evidence suggests that inflammation plays a role in the pathogenesis of bipolar disorder and that… Expand
Effects of lithium on lipopolysaccharide-induced inflammation in rat primary glia cells
Lithium is the gold-standard treatment for bipolar disorder, a severe mental illness. A large body of evidence suggests that inflammation plays a role in the pathogenesis of bipolar disorder and that… Expand
Effects of estrogen against LPS-induced inflammation and toxicity in primary rat glial and neuronal cultures
Several lines of evidence link inflammation with neurodegenerative diseases, which are aggravated by the age-related decline in estrogen levels in postmenopausal women. Lipopolysaccharide (LPS) is… Expand
Anti-Inflammatory Activity of Natural Products
This article presents highlights of the published literature regarding the anti-inflammatory activities of natural products. Many review articles were published in this regard, however, most of them… Expand
Glycogen synthase kinase‐3 is required for optimal de novo synthesis of inositol
- A. Azab, Q. He, S. Ju, Guiling Li, M. L. Greenberg
- Medicine, Biology
- Molecular microbiology
- 1 February 2007
Studies have shown that the inositol biosynthetic pathway and the enzyme glycogen synthase kinase‐3 (GSK‐3) are targets of the mood‐stabilizing drugs lithium and valproate. However, a relationship… Expand
Time-dependent effect of LPS on PGE2 and TNF-α production by rat glial brain culture: influence of COX and cytokine inhibitors
This study was undertaken to investigate the effect of lipopolysaccharide (LPS) stimulation on the time course of prostaglandin E2 (PGE) and tumor necrosis factor alpha (TNF-α) production by rat… Expand
Inositol phosphates and phosphoinositides in health and disease.
In the past two decades, considerable progress has been made toward understanding inositol phosphates and PI metabolism. However, there is still much to learn. The present challenge is to understand… Expand
Involvement of eicosanoids in the hypothermic response to lipopolysaccharide during endotoxemia in rats.
Hypothermia is one of the prominent features of the acute phase response to endotoxin (LPS). This study was undertaken to elucidate the effects of the COX-inhibitor Indomethacin (INDO) and the… Expand
Inhibition of prostaglandins does not reduce the cardiovascular changes during endotoxemia in rats.
- A. Azab, S. Kobal, M. Rubin, J. Kaplanski
- Biology, Medicine
- Prostaglandins, leukotrienes, and essential fatty…
- 1 February 2006
Vasodilatory prostanoids, such as prostacyclin and PGE2, and pro-inflammatory cytokines are known to play a central role in the pathogenesis of endotoxemia. This study was undertaken to elucidate… Expand
Nimesulide prevents lipopolysaccharide-induced elevation in plasma tumor necrosis factor-alpha in rats.
The present study was undertaken to test the hypothesis of possible inhibitory effect of nimesulide (4-nitro-2-phenoxymethane-sulfoxide) on plasma TNF-alpha level. Male Sprague-Dawley rats were… Expand