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The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems--a review.
Poly(D,L-lactic-co-glycolic acid) (PLGA) is the most frequently used biodegradable polymer in the controlled release of encapsulated drugs. Understanding the release mechanisms, as well as whichExpand
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Comparison of different flowability tests for powders for inhalation
A series of placebo powders for inhalation was characterized regarding bulk density and powder flowability using different techniques. The powders were of the ordered mixture type and were preparedExpand
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Diffusion in gels containing immobilized cells: A critical review
Eleven experimental investigation of diffusion in gels containing immobilized cells are reviewed. The experimental data, which quantitatively express the diffusion coefficient as a function of theExpand
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Economic evaluation of preconcentration in production of ethanol from dilute sugar solutions
The economic feasibility of preconcentrating dilute sugar solutions prior to fermentation is investigated. Two methods, evaporation and reverse osmosis, are compared. A computer program to determineExpand
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Atomic force microscopy analysis and confocal Raman microimaging of coated pellets.
Polymer-coated pellets with different coating thicknesses have been studied regarding coating morphology and drug release properties with atomic force microscopy (AFM) and confocal Raman microscopy.Expand
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Mechanistic modelling of drug release from polymer-coated and swelling and dissolving polymer matrix systems.
The time required for the design of a new delivery device can be sensibly reduced if the release mechanism is understood and an appropriate mathematical model is used to characterize the system. OnceExpand
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Effect of hindered diffusion on the adsorption of proteins in agarose gel using a pore model.
The hindered diffusion and binding of proteins of different sizes (lysozyme, BSA and IgG) in an agarose gel is described using adsorption kinetic and diffusional data together with an experimentallyExpand
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Coated formulations: new insights into the release mechanism and changes in the film properties with a novel release cell.
The effect of the blend ratio of water-insoluble ethyl cellulose (EC) and water-soluble hydroxypropyl cellulose (HPC-LF), on the properties of sprayed films and on the drug release mechanism ofExpand
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Model-based optimization of a preparative ion-exchange step for antibody purification.
A method using a model-based approach to design and optimize an ion-exchange step in a protein purification process is proposed for the separation of IgG from a mixture containing IgG, BSA andExpand
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Osmotic pumping release from ethyl-hydroxypropyl-cellulose-coated pellets: a new mechanistic model.
A new mechanistic model of drug release by osmotic pumping and diffusion from pellets coated with a semipermeable film developing pores created by the leaching of water-soluble compounds initiallyExpand
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