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TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1.
TAR deoxyribonucleic acid-binding protein 43 (TDP-43) is a multifunctional protein with roles in transcription, pre-messenger ribonucleic acid (mRNA) splicing, mRNA stability and transport. TDP-43Expand
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Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the selective loss of upper and lower motor neurons, a cell type that is intrinsically more vulnerable thanExpand
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Alterations in stress granule dynamics driven by TDP-43 and FUS: a link to pathological inclusions in ALS?
Stress granules (SGs) are RNA-containing cytoplasmic foci formed in response to stress exposure. Since their discovery in 1999, over 120 proteins have been described to be localized to theseExpand
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G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA
The TDP-43 target G3BP1 is essential for a functional interaction between stress granules and processing bodies.
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How Cholesterol Constrains Glycolipid Conformation for Optimal Recognition of Alzheimer's β Amyloid Peptide (Aβ1-40)
Membrane lipids play a pivotal role in the pathogenesis of Alzheimer's disease, which is associated with conformational changes, oligomerization and/or aggregation of Alzheimer's β-amyloid (Aβ)Expand
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TDP-43 regulates the alternative splicing of hnRNP A1 to yield an aggregation-prone variant in amyotrophic lateral sclerosis
See Fratta and Isaacs (doi:10.1093/brain/awy091) for a scientific commentary on this article.The RNA binding proteins TDP-43 (encoded by TARDBP) and hnRNP A1 (HNRNPA1) are each mutated in certainExpand
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Erratum to: Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP
Erratum Since publication of our article [1] we have noticed that an error was introduced during the assembly of Fig. 1d (Fig. 1 here), resulting in the duplication of two panels. Specifically, lanesExpand
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Explorer G 3 BP 1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA
Publisher Rights Statement: This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (seeExpand
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Guided-wave acousto-optic diffraction in Zn:LiNbO3
The acousto-optic control of light in Zn-diffused LiNbO3 optical waveguides is demonstrated. The guided optical mode diffraction by the surface acoustic waves is consistent with the Klein and CookExpand
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Broadband Optical Receiver IC on InP
The principals of optical communication systems operating at 10 Gbps and more are presented at this paper. A Transimpedance Amplifier (TIA) is the main part here. The Photo Diode current is a singleExpand
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