A. Auffret

Publications33
h-index18
Citations1,279
Highly Influential Citations26
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In vitro drug release studies of polymeric freeze-dried wafers and solvent-cast films using paracetamol as a model soluble drug.
Drug dissolution and release characteristics from freeze-dried wafers and solvent-cast films prepared from sodium carboxymethylcellulose (CMC) have been investigated to determine the mechanisms of… Expand
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Polypeptide ligation occurs during post-translational modification of concanavalin A
Lectins are proteins with multivalent carbohydrate-binding sites, which confer the ability to agglutinate. The seeds of legumes are particularly rich in lectins, for example, concanavalin A (Con A)… Expand
  • 211
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Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces
Solvent-cast films from three polymers, carboxymethylcellulose (CMC), sodium alginate (SA), and xanthan gum, were prepared by drying the polymeric gels in air. Three methods, (a) passive hydration,… Expand
  • 81
  • 3
The amino acid sequence of the aliphatic amidase from Pseudomonas aeruginosa
Amino acid sequence studies show that the aliphatic amidase (EC 3.5.1.4) from Pseudomonas aeruginosa PAC142 consists of a single polypeptide chain of 346 residues, giving an M r of 38400. The… Expand
  • 53
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Structure and topology of cytochrome f in pea chloroplast membranes
A transmembrane arrangement of cytochrome f in chloroplast thylakoid membranes, with the N-terminal heme-containing region in the intrathylakoid space and a 15 amino acid C-terminal sequence in the… Expand
  • 175
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The wheat chloroplast gene for CF0 subunit I of ATP synthase contains a large intron
The gene for CF0 subunit I of ATP synthase has been located in wheat chloroplast DNA, between the genes for CF0 subunit III and α subunit of CF1. Nucleotide sequencing and analysis of RNA‐DNA hybrids… Expand
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Lyophilised wafers as a drug delivery system for wound healing containing methylcellulose as a viscosity modifier.
Lyophilised wafers have potential as drug delivery systems for suppurating wounds. A dual series of wafers made from low molecular weight sodium alginate (SA) and xanthan gum (XG) respectively,… Expand
  • 67
  • 2
Comparison of the in vitro release characteristics of mucosal freeze-dried wafers and solvent-cast films containing an insoluble drug
Drug release characteristics of freeze-dried wafers and solvent-cast films prepared from sodium carboxymethylcellulose have been investigated and compared. In vitro drug dissolution studies were… Expand
  • 26
  • 2
Solid-phase sequence analysis of polypeptides eluted from polyacrylamide gels. An aid to interpretation of DNA sequences exemplified by the Escherichia coli unc operon and bacteriophage lambda.
An approach to sequencing proteins by the solid-phase method combined with isolation of proteins and polypeptides by gel electrophoresis is described. Mixtures of proteins or polypeptides resulting… Expand
  • 69
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Structural comparisons of superoxide dismutases.
The amino-terminal sequences of superoxide dismutase isolated from seven microorganisms have been determined. These include the first sequences of enzyme from anaerobic phototrophes. Five enzymes… Expand
  • 71
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