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Widespread A-to-I RNA Editing of Alu-Containing mRNAs in the Human Transcriptome
RNA editing by adenosine deamination generates RNA and protein diversity through the posttranscriptional modification of single nucleotides in RNA sequences. Few mammalian A-to-I edited genes haveExpand
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Cell cycle phase specificity of putative cyclin-dependent kinase variants in synchronized alfalfa cells.
The eukaryotic cell division cycle is coordinated by cyclin-dependent kinases (CDKs), represented by a single major serine/threonine kinase in yeasts (Cdc2/CDC28) and a family of kinases (CDK1 toExpand
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Nutritional control of body size through FoxO-Ultraspiracle mediated ecdysone biosynthesis
Despite their fundamental importance for body size regulation, the mechanisms that stop growth are poorly understood. In Drosophila melanogaster, growth ceases in response to a peak of the moltingExpand
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Alternative Splicing and Gene Duplication in the Evolution of the FoxP Gene Subfamily
The FoxP gene subfamily of transcription factors is defined by its characteristic 110 amino acid long DNA-binding forkhead domain and plays essential roles in vertebrate biology. Its four members,Expand
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Intracellular Targeting of Gag Proteins of the Drosophila Telomeric Retrotransposons
ABSTRACT Drosophila has two non-long-terminal-repeat (non-LTR) retrotransposons that are unique because they have a defined role in chromosome maintenance. These elements, HeT-A and TART, extendExpand
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Intron Retention in the 5′UTR of the Novel ZIF2 Transporter Enhances Translation to Promote Zinc Tolerance in Arabidopsis
Root vacuolar sequestration is one of the best-conserved plant strategies to cope with heavy metal toxicity. Here we report that zinc (Zn) tolerance in Arabidopsis requires the action of a novelExpand
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Zalpha-domains: at the intersection between RNA editing and innate immunity.
  • A. Athanasiadis
  • Biology, Medicine
  • Seminars in cell & developmental biology
  • 1 May 2012
The involvement of A to I RNA editing in antiviral responses was first indicated by the observation of genomic hyper-mutation for several RNA viruses in the course of persistent infections. However,Expand
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Conserved Fever Pathways across Vertebrates: A Herpesvirus Expressed Decoy TNF-α Receptor Delays Behavioral Fever in Fish
Summary Both endotherms and ectotherms (e.g., fish) increase their body temperature to limit pathogen infection. Ectotherms do so by moving to warmer places, hence the term “behavioral fever.” WeExpand
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Structural basis for Z-DNA binding and stabilization by the zebrafish Z-DNA dependent protein kinase PKZ
The RNA-dependent protein kinase PKR plays a central role in the antiviral defense of vertebrates by shutting down protein translation upon detection of viral dsRNA in the cytoplasm. In some teleostExpand
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Protein analysis and gene expression indicate differential vulnerability of Iberian fish species under a climate change scenario
Current knowledge on the biological responses of freshwater fish under projected scenarios of climate change remains limited. Here, we examine differences in the protein configuration of two endemicExpand
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