A. Astrup

Publications1,170
h-index118
Citations72,837
Highly Influential Citations2,175
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Obesity : Preventing and managing the global epidemic
Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies
TLDR
VAS scores are reliable for appetite research and do not seem to be influenced by prior diet standardization, however, consideration should be given to the specific parameters being measured, their sensitivity and study power.
Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans.
TLDR
The results show that GLP-1 enhanced satiety and reduced energy intake and thus may play a physiological regulatory role in controlling appetite and energy intake in humans.
A randomized trial of the effects of dietary counseling on gestational weight gain and glucose metabolism in obese pregnant women
TLDR
Restriction of gestational weight gain in obese women is achievable and reduces the deterioration in the glucose metabolism.
Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials
TLDR
The findings suggest that 20 mg per day rimonabant increases the risk of psychiatric adverse events--ie, depressed mood disorders and anxiety-despite depressed mood being an exclusion criterion in these trials.
Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans.
TLDR
The inverse relationship between plasma adip onectin and cytokines in vivo and the cytokine-induced reduction in adiponectin mRNA in vitro suggests that endogenous cytokines may inhibit adiponECTin.
Sucrose compared with artificial sweeteners: different effects on ad libitum food intake and body weight after 10 wk of supplementation in overweight subjects.
TLDR
Overweight subjects who consumed fairly large amounts of sucrose (28% of energy), mostly as beverages, had increased energy intake, body weight, fat mass, and blood pressure after 10 wk, and these effects were not observed in a similar group of subjects who consume artificial sweeteners.
The role of postprandial releases of insulin and incretin hormones in meal-induced satiety—effect of obesity and weight reduction
TLDR
Following weight reduction, GLP-1 response in the obese subjects apparently rose to a level between that of obese and lean subjects, and the data suggests that postprandial insulin and GIP responses are key players in short-term appetite regulation.
Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: a 6-mo randomized intervention study.
TLDR
Daily intake of SSSDs for 6 mo increases ectopic fat accumulation and lipids compared with milk, diet cola, and water, and is likely to enhance the risk of cardiovascular and metabolic diseases.
Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study
TLDR
Liraglutide treatment over 20 weeks is well tolerated, induces weight loss, improves certain obesity-related risk factors, and reduces prediabetes.
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