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Myogenic specification of side population cells in skeletal muscle
TLDR
Data document that satellite cells and muscle- derived stem cells represent distinct populations and demonstrate that muscle-derived stem cells have the potential to give rise to myogenic cells via a myocyte-mediated inductive interaction. Expand
Reduced Differentiation Potential of Primary MyoD−/− Myogenic Cells Derived from Adult Skeletal Muscle
TLDR
Northern analysis and Mixing of lacZ-labeled MyoD−/− cells and wild-type myoblasts revealed a strict autonomy in differentiation potential, and interpret these data to suggest that Myo D−/+ myogenic cells represent an intermediate stage between a quiescent satellite cell and a myogenic precursor cell. Expand
MyoD and Myf-5 differentially regulate the development of limb versus trunk skeletal muscle.
TLDR
The hypothesis that Myf-5 and MyoD have different roles in the development of epaxial and hypaxial musculature is supported, and results suggest that My f-5 expression in the limb is insufficient for the normal progression of myogenic development. Expand
Muscle satellite cells are multipotential stem cells that exhibit myogenic, osteogenic, and adipogenic differentiation.
TLDR
Results strongly suggest that muscle satellite cells possess multipotential mesenchymal stem cell activity and are capable of forming osteocytes and adipocytes as well as myocytes. Expand
The regulation of MyoD gene expression: conserved elements mediate expression in embryonic axial muscle.
TLDR
The functional conservation of the regulatory region of the mouse myoD gene in Xenopus embryos suggests that the regulatory pathway that activates myo D gene transcription in axial muscles is conserved among vertebrates. Expand
Constitutive Notch Activation Upregulates Pax7 and Promotes the Self-Renewal of Skeletal Muscle Satellite Cells
TLDR
A role of Notch signaling is established in actively promoting the self-renewal of muscle stem cells through direct regulation of Pax7 and in striking contrast to previous observations, NICDOE also inhibits S-phase entry and Ki67 expression and thus reduces the proliferation of primary myoblasts. Expand
MyoD regulates apoptosis of myoblasts through microRNA-mediated down-regulation of Pax3
TLDR
Suppression of the myogenic transcription factor MyoD is required for maintenance of muscle stem cells in mice and is associated with down-regulation in the immune system. Expand
Side population cells from diverse adult tissues are capable of in vitro hematopoietic differentiation.
TLDR
Hoechst-FACS analysis demonstrated that all adult tissues examined contained SP cells that were enriched for cells that exhibit hematopoietic potential, and cell preparations from nonhematopoetic tissues, such as skeletal muscle, kidney, lung, and small intestine, displayed markedly higher hematocarbon formation activity compared to peripheral blood cells. Expand
NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family
TLDR
The noncongruent expression pattern and target gene specificity of these highly related neurogenic bHLH proteins make them candidates for conferring specific aspects of the neuronal phenotype. Expand
MyoD induces myogenic differentiation through cooperation of its NH2- and COOH-terminal regions
TLDR
Together, these results support the notion that Myf5 functions toward myoblast proliferation, whereas MyoD prepares myoblasts for efficient differentiation. Expand
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