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Constitutive Notch Activation Upregulates Pax7 and Promotes the Self-Renewal of Skeletal Muscle Satellite Cells
ABSTRACT Notch signaling is a conserved cell fate regulator during development and postnatal tissue regeneration. Using skeletal muscle satellite cells as a model and through myogenic cellExpand
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Increased survival of muscle stem cells lacking the MyoD gene after transplantation into regenerating skeletal muscle
MyoD is a myogenic master transcription factor that plays an essential role in muscle satellite cell (muscle stem cell) differentiation. To further investigate the function of MyoD in satelliteExpand
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Muscle satellite cell heterogeneity and self-renewal
Adult skeletal muscle possesses extraordinary regeneration capacities. After muscle injury or exercise, large numbers of newly formed muscle fibers are generated within a week as a result ofExpand
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Open Access
Cloning and Nucleotide Sequencing of the Membrane-Bound l-Sorbosone Dehydrogenase Gene of Acetobacter liquefaciens IFO 12258 and Its Expression in Gluconobacter oxydans.
Volume 61, no. 2, p. 419, column 1, lines 15-19: this sentence should read as follows. "The alcohol dehydrogenase and glucose dehydrogenase have a common region reported to be related toExpand
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Open Access
Vascular-targeted therapies for Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy and an X-linked recessive, progressive muscle wasting disease caused by the absence of a functional dystrophin protein.Expand
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Promotion of Myoblast Differentiation by Fkbp5 via Cdk4 Isomerization
SUMMARY Fkbp5 is a widely expressed peptidyl prolyl isomerase that serves as a molecular chaperone through conformational changes of binding partners. Although it regulates diverse protein functions,Expand
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Isolation, culture, and transplantation of muscle satellite cells.
Muscle satellite cells are a stem cell population required for postnatal skeletal muscle development and regeneration, accounting for 2-5% of sublaminal nuclei in muscle fibers. In adult muscle,Expand
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Angiogenesis as a novel therapeutic strategy for Duchenne muscular dystrophy through decreased ischemia and increased satellite cells
Duchenne muscular dystrophy (DMD) is the most common hereditary muscular dystrophy caused by mutation in dystrophin, and there is no curative therapy. Dystrophin is a protein which forms theExpand
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Open Access
Myosin light chain 3f attenuates age‐induced decline in contractile velocity in MHC type II single muscle fibers
Aging is characterized by a progressive loss of muscle mass and impaired contractility (e.g., decline in force, velocity, and power). Although the slowing of contraction speed in aging muscle is wellExpand
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13 – Cellular and Molecular Mechanisms Regulating Skeletal Muscle Development
This chapter discusses the cellular and molecular mechanisms regulating skeletal muscle development. The study of skeletal muscle differentiation has been intensive since the 1960s because of readilyExpand
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