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HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium.
Hox genes are well-known transcriptional regulators that play an essential role in directing embryonic development. Mice that are homozygous for a targeted disruption of the Hoxa10 gene exhibitExpand
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Interactions of cytokines, growth factors, and the extracellular matrix in the cellular biology of uterine leiomyomata.
OBJECTIVE To review the available information regarding the role of cytokines, growth factors, and the extracellular matrix in the pathophysiology of uterine leiomyomata and to integrate thisExpand
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HOX gene expression is altered in the endometrium of women with endometriosis.
HOXA10 and HOXA11 are homeobox genes that function as transcription factors essential to embryonic development. We have recently described a role for each of these two genes in regulating endometrialExpand
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Endometriosis and Infertility
Endometriosis is an estrogen‐dependent disorder defined as the presence of endometrial tissue outside of the uterine cavity. A leading cause of infertility, endometriosis has a prevalence of 0.5–5%Expand
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Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in human endometrium.
Implantation is the process by which the blastocyst becomes intimately connected with the maternal endometrium/decidua. The independently developing preimplantation blastocyst then becomes dependentExpand
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Uterine Chemokines in Reproductive Physiology and Pathology
PROBLEM: Chemokines are increasingly recognized as important regulators of uterine function.
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Transforming growth factor-β3 is expressed at high levels in leiomyoma where it stimulates fibronectin expression and cell proliferation
OBJECTIVE: To investigate the expression of TGF-beta3 in leiomyoma and myometrium as well as the effect of TGF-beta3 on the expression of fibronectin and on the proliferation of leiomyoma andExpand
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Transforming growth factor-beta3 is expressed at high levels in leiomyoma where it stimulates fibronectin expression and cell proliferation.
OBJECTIVE To investigate the expression of TGF-beta3 in leiomyoma and myometrium as well as the effect of TGF-beta3 on the expression of fibronectin and on the proliferation of leiomyoma andExpand
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Leukocytes in ovarian function.
It has become apparent that in the ovary, the immune system contributes to the regulation of gonadal function. Leukocytes present within the ovary may constitute potential in-situ modulators ofExpand
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Local Cytokines in Endometrial Tissue: The Role of Interleukin‐8 in the Pathogenesis of Endometriosis
  • A. Arici
  • Medicine, Biology
  • Annals of the New York Academy of Sciences
  • 1 March 2002
Abstract: Endometriosis, defined by the presence of viable endometrial tissue outside the uterine cavity, is among the most common gynecologic disorders affecting women of reproductive age.Expand
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