Gibbs free energy of formation of chlordecone and potential degradation products: implications for remediation strategies and environmental fate.
- J. Dolfing, I. Novák, A. Archelas, H. Macarie
- ChemistryEnvironmental Science and Technology
- 10 July 2012
The results indicate that there are no thermodynamic reasons why chlordecone-respiring or -fermenting organisms should not exist and their Gibbs free energy and redox potential are calculated.
Directed evolution of an enantioselective epoxide hydrolase: uncovering the source of enantioselectivity at each evolutionary stage.
- M. Reetz, M. Bocola, S. Mowbray
- Chemistry, BiologyJournal of the American Chemical Society
- 11 May 2009
Experimental and computational results support a model in which productive positioning of the preferred (S)-glycidyl phenyl ether, but not the (R)-enantiomer, forms the basis of enhanced enantioselectivity.
Cloning and molecular characterization of a soluble epoxide hydrolase from Aspergillus niger that is related to mammalian microsomal epoxide hydrolase.
The isolation of the gene and cDNA for the A. niger EH by use of inverse PCR yielded a fully active EH with similar characteristics to the fungal enzyme and offers a versatile tool for the bio-organic chemist for the chiral synthesis of a variety of fine chemicals.
Enhancing the enantioselectivity of an epoxide hydrolase by directed evolution.
- M. Reetz, Claudia Torre, R. Furstoss
- Chemistry, BiologyOrganic Letters
- 22 January 2004
[reaction: see text] The epoxide hydrolase (EH) from Aspergillus niger, which shows a selectivity factor of only E = 4.6 in the hydrolytic kinetic resolution of glycidyl phenyl ether, has been…
Epoxide Hydrolases and their Application in Organic Synthesis
- M. Kotik, A. Archelas, Roland Wohlgemuth
- Chemistry
- 31 January 2012
Enzymatic transformations. Part 58: Enantioconvergent biohydrolysis of styrene oxide derivatives catalysed by the Solanum tuberosum epoxide hydrolase
- M. I. Monterde, M. Lombard, A. Archelas, A. Cronin, M. Arand, R. Furstoss
- Chemistry, Biology
- 20 September 2004
Access to enantiopure aromatic epoxides and diols using epoxide hydrolases derived from total biofilter DNA
- M. Kotik, V. Štěpánek, Michal Grulich, P. Kyslík, A. Archelas
- Chemistry, Biology
- 1 August 2010
Microbiological Transformations. 33. Fungal Epoxide Hydrolases Applied to the Synthesis of Enantiopure Para-Substituted Styrene Oxides. A Mechanistic Approach.
- S. Pedragosa-Moreau, C. Morisseau, J. Zylber, A. Archelas, J. Baratti, R. Furstoss
- Chemistry, BiologyJournal of Organic Chemistry
- 18 October 1996
The biohydrolysis of differently para-substituted styrene oxide derivatives was studied, using whole cells of the fungi Aspergillus niger or Beauveria sulfurescens, which proved to be enantiocomplementary.
Purification and characterization of a highly enantioselective epoxide hydrolase from Aspergillus niger.
- C. Morisseau, A. Archelas, C. Guitton, D. Faucher, R. Furstoss, J. Baratti
- Biology, ChemistryEuropean Journal of Biochemistry
- 15 July 1999
The epoxide hydrolase from Aspergillus niger was purified to homogeneity using a four-step procedure and p-nitrostyrene oxide (pNSO) as substrate and Hydrolysis of pNSO was highly enantioselective, with an E value of 40 and a high regioselectivity for the less hindered carbon atom of the epoxide.
Enzymatic Transformations 63. High‐Concentration Two Liquid‐Liquid Phase Aspergillus niger Epoxide Hydrolase‐Catalysed Resolution: Application to Trifluoromethyl‐Substituted Aromatic Epoxides
- J. Deregnaucourt, A. Archelas, F. Barbirato, J. Paris, R. Furstoss
- Chemistry, Biology
- 4 June 2007
The results amply demonstrated that the biocatalysed hydrolytic kinetic resolution of epoxides is nowadays to be considered as a very effi- cient, mild, cheap and easy-to-use "green chemistry" methodology applicable for cost effective preparative scale implementation.
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