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TRH site-specific methylation in oral and oropharyngeal squamous cell carcinoma
Among the 27,578 differentially methylated CpG sites, cg01009664 of the thyrotropin-releasing hormone (TRH) gene showed the greatest difference in methylation level between healthy and cancerous cells, and was demonstrated as a potential biomarker for OSCC and oropharyngeal SCC screening using oral rinse and swab techniques.
Head and neck squamous cell carcinoma drives long interspersed element-1 hypomethylation in the peripheral blood mononuclear cells.
The data supported that the alteration of LINE-1 methylation levels in PBMCs was influenced by HNSCC secretions, and the unmethylated Line-1 allele of PB MCs was proved to be an effective tumor marker and possesses a potential as HNS CC diagnostic tool.
Induction of ZCCHC6 Expression in Peripheral Blood Mononuclear Cells by HNSCC Secretions.
It is demonstrated that the secretion of HNSCC cells could cause the alterations in messenger RNA expression by PBMCs, and the ZCCHC6 expression level may apply in H NSCC screening.
Evaluation of NID2 promoter methylation for screening of Oral squamous cell carcinoma
The methylated NID2-relied quantitative PCR approach has demonstrated that this marker assists in distinguishing among patients with OSCC from normal oral epithelia, smokers, and patients with oral lichen planus using the non-invasive oral rinse and swab samples.
Transcriptomic Analysis of Peripheral Blood Mononuclear Cells in HNSCC Patients.
It is demonstrated that HMGN2 expression had a tendency to increase in both OC and OPC patients compared with HC, and the plasma HM GN2 (HMG-17) protein level exhibited the same trend as that observed at the transcriptional level.
Evaluation of lymphocyte apoptosis in patients with oral cancer
The Bax/Bcl-2 ratio in lymphocytes may be useful to determine the prognosis of OC patients, and could be considered a mean for supportive treatment in the future.