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Dermal sensitization quantitative risk assessment (QRA) for fragrance ingredients.
Exposure data for cosmetic products: lipstick, body lotion, and face cream.
Exposure data for personal care products: hairspray, spray perfume, liquid foundation, shampoo, body wash, and solid antiperspirant.
Toxicological profile of diethyl phthalate: a vehicle for fragrance and cosmetic ingredients.
- A. Api
- Environmental ScienceFood and chemical toxicology : an international…
- 1 February 2001
Exposure data for cosmetic products: facial cleanser, hair conditioner, and eye shadow.
Implementation of the dermal sensitization Quantitative Risk Assessment (QRA) for fragrance ingredients.
Potency values from the local lymph node assay: application to classification, labelling and risk assessment.
Allergic contact dermatitis: epidemiology, molecular mechanisms, in vitro methods and regulatory aspects
Research highlights included: advances in understanding of immune responses to contact sensitisers, the importance of autoxidation or enzyme-mediated oxidation for the activation of chemicals, the mechanisms through which hapten-protein conjugates are formed and the development of novel in vitro strategies for the identification of skin-sensitising chemicals.
Integrated Testing Strategies (ITS) for safety assessment.
The case of skin sensitization was taken as an example to understand how possible ITS can be constructed, optimized and validated, and will require embracing and developing new concepts such as adverse outcome pathways (AOP), advanced statistical learning algorithms and machine learning, mechanistic validation and "Good ITS Practices".
Use of an aggregate exposure model to estimate consumer exposure to fragrance ingredients in personal care and cosmetic products.