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Norbin Is an Endogenous Regulator of Metabotropic Glutamate Receptor 5 Signaling
It is reported that Norbin, a neuron-specific protein, physically interacts with mGluR5 in vivo, increases the cell surface localization of the receptor, and positively regulates mGLUR5 signaling.
Why rare diseases are an important medical and social issue
Ouabain, a steroid hormone that signals with slow calcium oscillations
- O. Aizman, P. Uhlén, M. Lal, H. Brismar, A. Aperia
- BiologyProceedings of the National Academy of Sciences…
- 30 October 2001
It is shown in renal epithelial cells that ouabain, in doses causing only partial Na,K-ATPase inhibition, acts as a biological inducer of regular, low-frequency intracellular calcium ([Ca2+]i) oscillations that elicit activation of the transcription factor, NF-κB.
Anatomical and physiological evidence for D1 and D2 dopamine receptor colocalization in neostriatal neurons
Confocal microscopy is used to demonstrate that virtually all striatal neurons, both in vitro and in vivo, contained dopamine receptors of both D1 and D2 classes of receptors, and functional evidence for such colocalization is provided.
Intrarenal dopamine: a key signal in the interactive regulation of sodium metabolism.
- A. Aperia
- Biology, MedicineAnnual review of physiology
A broad understanding of the renal dopamine system has become increasingly important, since there is now strong evidence from both clinical and experimental studies that dysregulation of the kidneys' dopamine system plays a role in many forms of multigenetic hypertension.
Identification of a molecular target for glutamate regulation of astrocyte water permeability
It is reported that glutamate increases astrocyte water permeability and that the molecular target for this effect is the aquaporin‐4 (AQP4) serine 111 residue, which is in a strategic position for control of the water channel gating.
Cell Signaling Microdomain with Na,K-ATPase and Inositol 1,4,5-Trisphosphate Receptor Generates Calcium Oscillations*
It is reported that Na,K-ATPase and inositol 1,4,5-trisphosphate ( InsP3) receptor (InsP3R) form a cell signaling microdomain that, in the presence of ouabain, generates slow Ca2+ oscillations in renal cells.
Water permeability of aquaporin-4 is decreased by protein kinase C and dopamine.
- M. Zelenina, S. Zelenin, A. Bondar, H. Brismar, A. Aperia
- BiologyAmerican journal of physiology. Renal physiology
- 1 August 2002
It is concluded that PKC and dopamine decrease AQP4 water permeability via phosphorylation at Ser180 and that the effect is likely mediated by gating of the channel.
Regulation of brain aquaporins
Nickel and Extracellular Acidification Inhibit the Water Permeability of Human Aquaporin-3 in Lung Epithelial Cells*
It is shown that nickel inactivates aquaporin (AQP)-3, the water channel expressed apically in epithelial cells of human terminal airways, implying that nickel and extracellular pH may modulate lung water clearance and that defective water clearance may be an early component of nickel-induced lung disease.