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Polysulfides as biologically active ingredients of garlic.
TLDR
The chemistry underlying the biological activity of these polysulfides is currently emerging seems to include a combination of several distinct transformations, such as oxidation reactions, superoxide radical and peroxide generation, decomposition with release of highly electrophilic S(x) species, inhibition of metalloenzymes, disturbance of metal homeostasis and membrane integrity and interference with different cellular signalling pathways. Expand
Antiproliferative effect of natural tetrasulfides in human breast cancer cells is mediated through the inhibition of the cell division cycle 25 phosphatases.
TLDR
The inhibitory activity of tetrasulfides occurring naturally in garlic and onion towards the human Cdc25 phosphatases is reported on, suggesting phosphatase CDC25 as possible targets of naturally occuring polysulfides contributing to their anticancer properties. Expand
The natural organosulfur compound dipropyltetrasulfide prevents HOCl-induced systemic sclerosis in the mouse
TLDR
The natural organosulfur compound DPTTS prevents skin and lung fibrosis in the mouse through the selective killing of diseased fibroblasts and its immunomodulating properties. Expand
Cell cycle arrest in early mitosis and induction of caspase-dependent apoptosis in U937 cells by diallyltetrasulfide (Al2S4)
TLDR
It is found that the compounds tested in this study induced apoptosis in U937 cells, with an efficiency depending on the number of sulfides, and selected the most promising candidate, diallyltetrasulfide (Al2S4), for detailed mechanistic studies. Expand
Perspective on recent developments on sulfur-containing agents and hydrogen sulfide signaling.
TLDR
Future studies will need to focus on how such compounds are formed and transformed in the relevant plants, how food processing affects their chemical constitution, and how they release hydrogen sulfide (or control its levels) in the human body. Expand
The chemistry behind redox regulation with a focus on sulphur redox systems.
TLDR
It has become apparent that the redox chameleon sulphur occurs in biological systems in about 10 different oxidation states, which give rise to an extensive and complicated network of sulphur-based redox events. Expand
Diallylpolysulfides induce growth arrest and apoptosis.
TLDR
It is found that the induction of apoptosis was indeed dependent on the redox-state of the cell, with anti-oxidants being able to prevent sulfide-induced apoptosis, and using HCT116 cells which were either positive or negative for p53 revealed that p53 is clearly dispensable for induction of induced apoptosis. Expand
Antimicrobial garlic-derived diallyl polysulfanes: Interactions with biological thiols in Bacillus subtilis.
TLDR
This study shows the rapid parallel impact of polysulfanes on different biologicalThiols inside Bacillus subtilis alongside the concomitant generation of allyl thiols and persulfides. Expand
Think Yellow and Keep Green—Role of Sulfanes from Garlic in Agriculture
TLDR
There seems to be a broad range of activity associated with the sulfur-containing compounds derived from Allium species, which manifests itself in diverse insecticidal, antifungal, and nematicidal activities, which open a new understanding to develop this natural chemistry as a “green pesticide”. Expand
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